The improvements in imaging technology opened up the possibility to investigate the structure and function of cerebral vasculature and the neurovascular unit with unprecedented precision and gaining deep insights not only on the morphology of the vessels but also regarding their function and regulation related to the cerebral activity. In this review, we will dissect the different imaging capabilities regarding the cerebrovascular tree, the neurovascular unit, the haemodynamic response function, and thus, the vascular–neuronal coupling. We will discuss both clinical and preclinical setting, with a final discussion on the current scenery in cerebrovascular imaging where magnetic resonance imaging and multimodal microscopy emerge as the most potent and versatile tools, respectively, in the clinical and preclinical context.

中文翻译：

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不同尺度的脑血管系统成像：研究神经血管接口的转化工具


成像技术的改进为以前所未有的精度研究脑血管系统和神经血管单位的结构和功能提供了可能性，不仅对血管的形态有了深入的了解，而且对它们的功能和与大脑活动相关的调节也有了深入的了解。在这篇综述中，我们将剖析关于脑血管树、神经血管单位、血流动力学反应功能以及血管-神经元耦合的不同成像能力。我们将讨论临床和临床前环境，最后讨论脑血管成像的现状，其中磁共振成像和多模态显微镜分别成为临床和临床前环境中最有效和最通用的工具。