Background The associations of physical pre-frailty and frailty with bone fractures and the modified effect of sedentary lifestyle remain uncertain. This study was performed to explore the association of physical pre-frailty and frailty with risk of incident bone fractures, and test the modification effects of sedentary lifestyle and other risk factors. Methods This cohort study included 413 630 participants without bone fractures at baseline in the UK Biobank study between 2006 and 2010 and followed up to 2021. The mean age of the participants was 56.5 years. A total of 224 351 (54.2%) enrolled participants were female and 376 053 (90.9%) included participants were White. Three Cox regression models were constructed to analyze the association of pre-frailty and frailty with total fractures, hip fractures, vertebrae fractures, and other fractures. Results As compared with the physical nonfrailty group, the multivariate-adjusted hazard ratios were 1.17 (95% confidence interval [CI]: 1.14–1.21) and 1.63 (95% CI: 1.53–1.74) for the physical pre-frailty group and frailty group, respectively (p-trend < .001). In addition, we found that sedentary behavior time significantly accentuated the associations of physical pre-frailty and frailty with total fractures (p-interaction <.001), hip fractures (p-interaction = .013), and other fractures (p-interaction <.001). Conclusions Our results indicate that physical pre-frailty and frailty are related to higher risks of bone fractures; such association was more pronounced among those with longer sedentary behavior time.

中文翻译：

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虚弱状态、久坐行为和骨折风险


背景 身体虚弱前期和虚弱与骨折的关联以及久坐不动的生活方式的改变影响仍然不确定。本研究旨在探讨身体衰弱前期和衰弱与骨折风险的关系，并测试久坐不动的生活方式和其他危险因素的改变效果。方法 该队列研究包括 413 630 名在 2006 年至 2010 年期间在英国生物样本库研究中基线时没有骨折的参与者，并随访至 2021 年。参与者的平均年龄为 56.5 岁。共有 224 351 名 （54.2%） 入组参与者为女性，纳入的参与者为 376 053 名 （90.9%） 为白人。构建 3 个 Cox 回归模型，分析衰弱前期和衰弱与全骨折、髋部骨折、椎骨骨折和其他骨折的相关性。结果 与身体非虚弱组相比，身体衰弱前组和虚弱组的多变量调整风险比分别为 1.17 （95% 置信区间 [CI]： 1.14-1.21） 和 1.63 （95% CI： 1.53-1.74） （p 趋势 < .001）。此外，我们发现久坐行为时间显著突出了身体虚弱前期和虚弱与全骨折 （p-交互作用 <.001）、髋部骨折 （p-交互作用 = .013） 和其他骨折 （p-交互作用 <.001） 的关联。结论 我们的结果表明，身体衰弱前期和衰弱与骨折风险较高有关;这种关联在久坐行为时间较长的人中更为明显。