Atherosclerosis remains the leading cause of death globally. Although its focal pathology is atheroma that develops in arterial walls, atherosclerosis is a systemic disease involving contributions by many organs and tissues. It is now established that the immune system causally contributes to all phases of atherosclerosis. Recent and emerging evidence positions the nervous system as a key modulator of inflammatory processes that underlie atherosclerosis. This neuroimmune cross-talk, we are learning, is bidirectional, and immune-regulated afferent signalling is becoming increasingly recognized in atherosclerosis. Here, we summarize data and concepts that link the immune and nervous systems in atherosclerosis by focusing on two important sites, the arterial vessel and the bone marrow.

中文翻译：

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斑块和骨髓中的神经免疫回路调节动脉粥样硬化


动脉粥样硬化仍然是全球死亡的主要原因。虽然其局灶性病变是在动脉壁发展的动脉粥样硬化，但动脉粥样硬化是一种涉及许多器官和组织贡献的全身性疾病。现在已经确定，免疫系统是动脉粥样硬化所有阶段的因果原因。最近和新出现的证据将神经系统定位为动脉粥样硬化基础炎症过程的关键调节剂。我们正在了解到，这种神经免疫串扰是双向的，免疫调节的传入信号在动脉粥样硬化中越来越受到认可。在这里，我们通过关注动脉血管和骨髓这两个重要部位，总结了将动脉粥样硬化中的免疫和神经系统联系起来的数据和概念。