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Antibacterial Iodine-Releasing Coatings of Cross-Linked Poly(N-vinylpyrrolidone) Synthesized by Solvent-Free Initiated Chemical Vapor Deposition
ACS Macro Letters ( IF 5.1 ) Pub Date : 2024-07-31 , DOI: 10.1021/acsmacrolett.4c00301
Qing Song 1 , Zihan Xiao 2, 3 , Tong Liu 1 , Haijun Gao 1 , Ximan Chen 1 , Qingyan Jia 3 , Peng Li 3 , Dahai Wei 4
Affiliation  

Biomaterial-associated infections caused by bacteria pose a great threat to human health, and therefore, various antibacterial coatings have been developed to control bacterial infections. Povidone iodine (PVP-I) is a broad-spectrum antimicrobial agent without drug resistance to most pathogenic microorganisms and has been widely used in the clinic. However, its applications in the field of coatings are limited due to its strong water solubility. Here, we used initiated Chemical Vapor Deposition (iCVD) technique to synthesize cross-linked poly(N-vinylpyrrolidone-co-ethylene glycol dimethacrylate) (PVE) coatings to firmly immobilize poly(N-vinylpyrrolidone) (PVP) on surfaces. After complexation with iodine, PVE-I coatings exhibited potent bacteria-killing and antifouling activities against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus in vitro owing to the antibacterial effect of iodine and the hydrophilicity of VP, respectively. The killing and antifouling effects were positively correlated with the VP content. The PVE-I-2 coating displayed excellent anti-infection performance in a rat subcutaneous implantation model in vivo. This study provided a simple method for preparing stable povidone iodine coatings on surfaces via solvent-free iCVD, and combined bacteria-killing and antifouling strategies to fabricate multifunctional antibacterial coatings against bacterial infections on biomaterial surfaces.

中文翻译:


无溶剂引发化学气相沉积合成交联聚(N-乙烯基吡咯烷酮)抗菌释碘涂料



由细菌引起的生物材料相关感染对人类健康构成巨大威胁,因此,人们开发了各种抗菌涂层来控制细菌感染。聚维酮碘(PVP-I)是一种广谱抗菌剂,对大多数病原微生物不产生耐药性,已广泛应用于临床。但由于其水溶性强,其在涂料领域的应用受到限制。在这里,我们使用化学气相沉积(iCVD)技术合成交联聚( N-乙烯基吡咯烷酮-共聚-乙二醇二甲基丙烯酸酯)(PVE)涂层,将聚( N-乙烯基吡咯烷酮)(PVP)牢固地固定在表面上。与碘络合后,由于碘的抗菌作用和VP的亲水性,PVE-I涂层在体外对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌分别表现出有效的杀菌和防污活性。杀灭、防污效果与VP含量呈正相关。 PVE-I-2涂层大鼠体内皮下植入模型中表现出优异的抗感染性能。本研究提供了一种通过无溶剂 iCVD 在表面制备稳定的聚维酮碘涂层的简单方法,并结合杀菌和防污策略来制备针对生物材料表面细菌感染的多功能抗菌涂层。
更新日期:2024-07-31
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