Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses,Cell Host & Microbe

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Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2024-08-01 , DOI: 10.1016/j.chom.2024.07.007
Daan F van den Berg ₁ , Ana Rita Costa ₁ , Jelger Q Esser ₁ , Ilinka Stanciu ₁ , Jasper Q Geissler ₁ , Adja Damba Zoumaro-Djayoon ₂ , Pieter-Jan Haas ₃ , Stan J J Brouns ₁

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Prokaryotes have evolved a multitude of defense systems to protect against phage predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here, we set out to systematically project the current knowledge of eukaryotic-like antiviral defense systems onto prokaryotic genomes, using as a model organism. Searching for phage defense systems related to innate antiviral genes from vertebrates and plants, we uncovered over 450 candidates. We validated six of these phage defense systems, including factors preventing viral attachment, R-loop-acting enzymes, the inflammasome, ubiquitin pathway, and pathogen recognition signaling. Collectively, these defense systems support the concept of deep evolutionary links and shared antiviral mechanisms between prokaryotes and eukaryotes.

中文翻译：

具有抗噬菌体活性的先天真核抗病毒防御的细菌同源物突出了病毒防御的共同进化根源

原核生物已经进化出多种防御系统来防止噬菌体捕食。其中一些类似于参与抗病毒反应的真核基因。在这里，我们着手将当前的类真核抗病毒防御系统知识系统地投射到原核基因组上，并用作模型生物。在寻找与脊椎动物和植物的先天抗病毒基因相关的噬菌体防御系统时，我们发现了超过 450 个候选噬菌体防御系统。我们验证了其中六个噬菌体防御系统，包括阻止病毒附着的因素、R 环作用酶、炎性体、泛素途径和病原体识别信号。总的来说，这些防御系统支持原核生物和真核生物之间深层进化联系和共享抗病毒机制的概念。

更新日期：2024-08-01

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