Macrophages regulate angiogenesis, repair, conduction, and homeostasis in heart tissue. Landau et al.¹ demonstrate that incorporating primitive macrophages into engineered heart tissues significantly promotes long-term vascularization and cardiac maturation. This advance demonstrates the importance of resident immune-vascular microenvironments in cardiac tissue engineering, marking an important step forward for heart-on-chip technologies.

中文翻译：

---

巨噬细胞：心脏组织工程中持续血管化缺失的关键

巨噬细胞调节心脏组织中的血管生成、修复、传导和稳态。兰道等人。^图1表明，将原始巨噬细胞纳入工程心脏组织可显着促进长期血管化和心脏成熟。这一进展证明了常驻免疫血管微环境在心脏组织工程中的重要性，标志着心脏芯片技术向前迈出了重要一步。