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Engineered vascular grafts lend unique insight to pathophysiology of aortic aneurysms
Cell Stem Cell ( IF 19.8 ) Pub Date : 2024-08-01 , DOI: 10.1016/j.stem.2024.07.002
Kaleb M Naegeli 1 , Laura E Niklason 1
Affiliation  

Yang et al.1 generate tissue engineered blood vessels from hiPSC-derived smooth muscle cells harboring a mutation found in Loeys-Dietz syndrome. In vitro and in vivo data from these vessels provide new insight into the molecular physiology of aortic aneurysms and may create a paradigm for understanding a suite of vascular diseases.



中文翻译:


工程血管移植物为主动脉瘤的病理生理学提供了独特的见解



杨等人。 1从 hiPSC 衍生的平滑肌细胞中生成组织工程血管,这些平滑肌细胞含有 Loeys-Dietz 综合征中发现的突变。来自这些血管的体外体内数据为主动脉瘤的分子生理学提供了新的见解,并可能为理解一系列血管疾病创建一个范例。

更新日期:2024-08-01
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