Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets,Gastroenterology

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Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets
Gastroenterology ( IF 25.7 ) Pub Date : 2024-07-30 , DOI: 10.1053/j.gastro.2024.07.025
Siyan Cao ₁ , Khai Nguyen ₂ , Kaiming Ma ₁ , Xiaotang Du ₂ , Xiuli Liu ₂ , Alina Ulezko Antonova ₂ , Richard P Rood ₁ , Anas Gremida ₁ , Chien-Huan Chen ₁ , Alexandra Gutierrez ₁ , Deborah C Rubin ₁ , Martin H Gregory ₁ , Mate Gergely ₁ , Guadalupe Oliva Escudero ₁ , Katherine Huang ₁ , Natalia Jaeger ₂ , Marina Cella ₂ , Rodney D Newberry ₁ , Nicholas O Davidson ₁ , Matthew A Ciorba ₁ , Parakkal Deepak ₁ , Marco Colonna ₂

Affiliation

The pathophysiology of Crohn’s-like disease of the pouch (CDP) in patients with a history of ulcerative colitis (UC) is unknown. We examined mucosal cells from patients with and without CDP using single-cell analyses.

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