Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing.,Protein & Cell

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Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing.
Protein & Cell ( IF 13.6 ) Pub Date : 2024-04-01 , DOI: 10.1093/procel/pwad058
Han Chen _{1,

2,

3,

4} , Mehar Monga _{2,

4,

5} , Qinghua Fang _{1,

2,

3} , Loujin Slitin _{1,

4,

6,

7} , Jakob Neef _{1,

2,

3} , Shashank S Chepurwar _{2,

4,

8} , Regina Célia Mingroni Netto ₉ , Karina Lezirovitz ₁₀ , Alfredo Tabith ₁₁ , Fritz Benseler ₁₂ , Nils Brose _{2,

12,

13} , Kathrin Kusch _{1,

14} , Carolin Wichmann _{2,

6,

7,

13} , Nicola Strenzke _{1,

2,

8} , Barbara Vona _{1,

15,

16} , Julia Preobraschenski _{2,

5,

13} , Tobias Moser _{1,

2,

3,

13}

Affiliation

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.
Auditory Neuroscience and Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.
Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.
Biochemistry of Membrane Dynamics Group, Institute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany.
Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany.
Auditory Systems Physiology Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
Departamento de Genética e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-220, Brazil.
Laboratório de Otorrinolaringologia/LIM32, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP 05508-220, Brazil.
DERDIC, Pontifícia Universidade Católica de São Paulo, São Paulo 05508-220, Brazil.
Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.
Multiscale Bioimaging Cluster of Excellence (MBExC), University of Göttingen, 37075 Göttingen, Germany.
Functional Auditory Genomics Group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, 37077 Göttingen, Germany.
Hearing Genomics Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
Institute of Human Genetics, University Medical Center Göttingen, 37075 Göttingen, Germany.