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Isoliquiritigenin Alleviates Diabetic Kidney Disease via Oxidative Stress and the TLR4/NF-κB/NLRP3 Inflammasome Pathway
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-07-31 , DOI: 10.1002/mnfr.202400215 Yanhong Wang 1, 2 , Jia Yang 1 , Xinyue Chang 1 , Yuan Xue 1 , Gaohong Liu 3 , Tingting Zhang 1 , Weihao Chen 1 , Weiping Fan 1 , Jihua Tian 1, 2 , Xiaojun Ren 4
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-07-31 , DOI: 10.1002/mnfr.202400215 Yanhong Wang 1, 2 , Jia Yang 1 , Xinyue Chang 1 , Yuan Xue 1 , Gaohong Liu 3 , Tingting Zhang 1 , Weihao Chen 1 , Weiping Fan 1 , Jihua Tian 1, 2 , Xiaojun Ren 4
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Diabetic kidney disease (DKD) is the primary factor that causes chronic kidney disease and causes increasing mortality and morbidity due to its severe consequences. Isoliquiritigenin (ISL) is the primary element of licorice root that is physiologically active and has antifree radical, antioxidation, and antiapoptotic properties. However, the effect of ISL on DKD is still unclear and needs to be further improved. This study aims to evaluate the renoprotective effects of ISL on diabetes-induced renal injury and explores the underlying mechanisms involved. Male C57BL/6 mice are fed a high-fat diet and then injected with streptozotocin for 2 consecutive days to establish a diabetic model, and high-glucose-treated NRK-52E cells are used to investigate the renoprotective effects of ISL in DKD. The results show that ISL significantly preserves renal function and architecture in DKD. ISL suppresses oxidative stress and reduces ROS levels, inhibiting the activation of the NF-κB and the NLRP3 inflammasome and the occurrence of pyroptosis. Moreover, the study finds that ISL can inhibit the mitochondrial apoptotic pathway. In addition, the study confirms the inhibitory effect of ISL on the TLR4/NF-κB/NLRP3 inflammasome pathway. These observations demonstrate that the natural flavonoid compound ISL can be a promising agent for the treatment of DKD.
中文翻译：
异甘草素通过氧化应激和 TLR4/NF-κB/NLRP3 炎症小体途径减轻糖尿病肾病
糖尿病肾病（DKD）是导致慢性肾脏病的主要因素，其严重后果导致死亡率和发病率不断增加。异甘草素（ISL）是甘草根的主要成分，具有生理活性，具有抗自由基、抗氧化和抗细胞凋亡的特性。但ISL对DKD的疗效尚不清楚，有待进一步完善。本研究旨在评估 ISL 对糖尿病肾损伤的肾脏保护作用，并探讨其潜在机制。雄性C57BL/6小鼠高脂饮食后连续2天注射链脲佐菌素建立糖尿病模型，并用高糖处理的NRK-52E细胞研究ISL对DKD的肾脏保护作用。结果表明，ISL 可显着保留 DKD 患者的肾功能和结构。 ISL抑制氧化应激并降低ROS水平，抑制NF-κB和NLRP3炎症小体的激活以及细胞焦亡的发生。而且，研究发现ISL可以抑制线粒体凋亡途径。此外，研究证实了ISL对TLR4/NF-κB/NLRP3炎症小体通路的抑制作用。这些观察结果表明，天然类黄酮化合物 ISL 可以成为治疗 DKD 的有前途的药物。
更新日期：2024-07-31
中文翻译：
异甘草素通过氧化应激和 TLR4/NF-κB/NLRP3 炎症小体途径减轻糖尿病肾病
糖尿病肾病（DKD）是导致慢性肾脏病的主要因素，其严重后果导致死亡率和发病率不断增加。异甘草素（ISL）是甘草根的主要成分，具有生理活性，具有抗自由基、抗氧化和抗细胞凋亡的特性。但ISL对DKD的疗效尚不清楚，有待进一步完善。本研究旨在评估 ISL 对糖尿病肾损伤的肾脏保护作用，并探讨其潜在机制。雄性C57BL/6小鼠高脂饮食后连续2天注射链脲佐菌素建立糖尿病模型，并用高糖处理的NRK-52E细胞研究ISL对DKD的肾脏保护作用。结果表明，ISL 可显着保留 DKD 患者的肾功能和结构。 ISL抑制氧化应激并降低ROS水平，抑制NF-κB和NLRP3炎症小体的激活以及细胞焦亡的发生。而且，研究发现ISL可以抑制线粒体凋亡途径。此外，研究证实了ISL对TLR4/NF-κB/NLRP3炎症小体通路的抑制作用。这些观察结果表明，天然类黄酮化合物 ISL 可以成为治疗 DKD 的有前途的药物。
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