Benzofuran and Benzo[b]thiophene-2-Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation,ChemMedChem

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Benzofuran and Benzo[b]thiophene-2-Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation
ChemMedChem ( IF 3.6 ) Pub Date : 2024-07-31 , DOI: 10.1002/cmdc.202400198
Yusheng Zhao ₁ , Kartar Singh ₁ , Rahul Chowdhary Karuturi ₁ , Ahmed A Hefny ₁ , Arash Shakeri ₁ , Michael A Beazely ₁ , Praveen Nekkar Rao ₂

Affiliation

A group of novel benzofuran and benzothiophene-based small molecules were designed, synthesized and evaluated as amyloid-beta aggregation modulators. The results obtained demonstrate that these class of molecules can be chemically modified to obtain either amyloid-beta aggregation inhibitors or promoters. These studies demonstrate their potential application to develop novel diagnostics and therapeutics for Alzheimer's disease.

中文翻译：

苯并呋喃和苯并[b]噻吩-2-甲酰胺衍生物作为β淀粉样蛋白 (Aβ42) 聚集的调节剂

设计、合成了一组新型苯并呋喃和苯并噻吩基小分子，并对其作为淀粉样蛋白-β 聚集调节剂进行了评估。获得的结果表明，可以对此类分子进行化学修饰以获得淀粉样蛋白-β聚集抑制剂或促进剂。这些研究证明了它们在开发阿尔茨海默病的新型诊断和治疗方法方面的潜在应用。

更新日期：2024-07-31

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