Benzofuran and Benzo[b]thiophene-2-Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation,ChemMedChem

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Benzofuran and Benzo[b]thiophene-2-Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation
ChemMedChem ( IF 3.6 ) Pub Date : 2024-07-31 , DOI: 10.1002/cmdc.202400198
Yusheng Zhao ₁ , Kartar Singh ₁ , Rahul Chowdhary Karuturi ₁ , Ahmed A Hefny ₁ , Arash Shakeri ₁ , Michael A Beazely ₁ , Praveen Nekkar Rao ₂

Affiliation

A group of novel benzofuran and benzothiophene-based small molecules were designed, synthesized and evaluated as amyloid-beta aggregation modulators. The results obtained demonstrate that these class of molecules can be chemically modified to obtain either amyloid-beta aggregation inhibitors or promoters. These studies demonstrate their potential application to develop novel diagnostics and therapeutics for Alzheimer's disease.

中文翻译：

苯并呋喃和苯并[b]噻吩-2-羧酰胺衍生物作为β淀粉样蛋白（Aβ42）聚集的调节剂

设计、合成了一组基于苯并噻吩的新型小分子，并评价了淀粉样蛋白-β 聚集调节剂。获得的结果表明，这些类别的分子可以通过化学修饰以获得淀粉样蛋白-β 聚集抑制剂或启动子。这些研究证明了它们在开发阿尔茨海默病的新型诊断和治疗方法方面的潜在应用。

更新日期：2024-07-31

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