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Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib
Leukemia ( IF 12.8 ) Pub Date : 2024-07-31 , DOI: 10.1038/s41375-024-02353-0 Ariel Leyte-Vidal 1, 2 , RosaAnna DeFilippis 1 , Ian R Outhwaite 3 , Isabelle Kwan 3, 4, 5 , Ji Young Lee 4 , Carlyn Leavitt 1 , Kaeli B Miller 1 , Delphine Rea 6 , Aziz M Rangwala 3 , Kevin Lou 7, 8 , Suhana Patel 1 , Ailin Alvarez 1 , Kevan M Shokat 7, 8, 9 , Ivet Bahar 4, 5 , Markus A Seeliger 3, 4 , Neil P Shah 1
中文翻译：
BCR：：ABL1 中不存在 ABL1 外显子 2 编码的 SH3 残基会破坏自身抑制的激酶构象并赋予对 asciminib 的耐药性
更新日期：2024-07-31
Leukemia ( IF 12.8 ) Pub Date : 2024-07-31 , DOI: 10.1038/s41375-024-02353-0 Ariel Leyte-Vidal 1, 2 , RosaAnna DeFilippis 1 , Ian R Outhwaite 3 , Isabelle Kwan 3, 4, 5 , Ji Young Lee 4 , Carlyn Leavitt 1 , Kaeli B Miller 1 , Delphine Rea 6 , Aziz M Rangwala 3 , Kevin Lou 7, 8 , Suhana Patel 1 , Ailin Alvarez 1 , Kevan M Shokat 7, 8, 9 , Ivet Bahar 4, 5 , Markus A Seeliger 3, 4 , Neil P Shah 1
Affiliation
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中文翻译：
BCR：：ABL1 中不存在 ABL1 外显子 2 编码的 SH3 残基会破坏自身抑制的激酶构象并赋予对 asciminib 的耐药性
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