Anti-nephrin autoantibodies: a paradigm shift in podocytopathies,Nature Reviews Nephrology

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Anti-nephrin autoantibodies: a paradigm shift in podocytopathies
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2024-07-30 , DOI: 10.1038/s41581-024-00873-7
Zhao Cui _{1,

2} , Ming-Hui Zhao _{1,

2}

Affiliation

A new study demonstrates that anti-nephrin autoantibodies are not merely markers but also actively contribute to the pathogenesis of minimal change disease and primary focal segmental glomerulosclerosis. This insight not only provides a non-invasive diagnostic alternative to kidney biopsies, but also suggests potential for novel targeted therapies.

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