The SRS Technique is a procedure that uses ionizing radiation usually in a single dose or in a maximum number of five fractions for the treatment of intracranial lesions. Multiple brain metastases single-isocenter stereotactic radiosurgery (SRS) treatment is increasingly employed in radiotherapy services. In this treatment is required that the prescription dose be restricted to the lesion only and have a pronounced dose decay in the adjacent healthy tissue. An extensive quality control program must be employed to ensure the quality of the entire treatment procedure. The purpose of this study was to investigate the use of alanine-EPR dosimeters as a dosimetric tool for quality control of the stereotactic radiosurgery procedure using the Volume Modulated Arc Technique (VMAT). The results showed that the alanine-EPR response is linear with the radiation dose in the range from 2 to 100 Gy, with a low dose rate and energy dependencies. The results of the doses measured with alanine in relation to the planned value for the four lesions were concordant, with differences smaller than 1.2%. The experiment enabled a comprehensive assessment of the entire SRS procedure, encompassing both the treatment planning and irradiation phases. Consequently, both mechanical and dosimetric parameters can be evaluated concurrently, allowing for a comprehensive assessment of the total inaccuracy of the procedure.

中文翻译：

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使用丙氨酸-EPR 剂量测定进行立体定向放射外科手术的质量控制


SRS 技术是一种通常使用单剂量或最多五次电离辐射来治疗颅内病变的手术。多发性脑转移瘤单等中心立体定向放射外科 (SRS) 治疗越来越多地应用于放射治疗服务。在这种治疗中，要求处方剂量仅限于病变部位，并且在邻近的健康组织中具有明显的剂量衰减。必须采用广泛的质量控制计划来确保整个治疗过程的质量。本研究的目的是研究丙氨酸-EPR 剂量计作为剂量测定工具的用途，用于使用体积调制弧技术 (VMAT) 进行立体定向放射外科手术的质量控制。结果表明，丙氨酸-EPR响应在2~100 Gy范围内与辐射剂量呈线性关系，且剂量率和能量依赖性较低。四个病灶的丙氨酸测量剂量结果与计划值一致，差异小于 1.2%。该实验能够对整个 SRS 手术进行全面评估，包括治疗计划和照射阶段。因此，可以同时评估机械和剂量参数，从而可以对程序的总体不准确性进行全面评估。