89Zr is a promising radionuclide for high-resolution PET imaging with radiolabelled monoclonal antibodies. In the present study, the possibility of 89Zr production from molybdenum targets was investigated using electron accelerators. The 89Zr activity yields were determined experimentally for bremsstrahlung with endpoint energies of 20 and 55 MeV. The amount of radioactive impurities and stable zirconium isotopes associated with the 89Zr produced was estimated using experimental results and the TALYS 1.96 code. The conditions for achieving a minimum level of zirconium by-product isotopes to meet the expected clinical requirements are discussed in the article. The reaction 92Mo (γ, p2n)89Nb→89Zr was found to be the most promising for photonuclear production. It can provide the highest purity of zirconium radionuclide and the lowest amount of zirconium stable isotopes. A major advantage of the proposed method will be the ability to use natural molybdenum targets.

中文翻译：

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使用电子加速器辐照钼生产 89Zr


89Zr 是一种很有前景的放射性核素，可用于放射性标记单克隆抗体的高分辨率 PET 成像。在本研究中，研究了使用电子加速器从钼靶材生产 89Zr 的可能性。 89Zr 活性产率通过实验确定了终点能量为 20 和 55 MeV 的轫致辐射。使用实验结果和 TALYS 1.96 代码估算了与生产的 89Zr 相关的放射性杂质和稳定锆同位素的量。本文讨论了达到最低水平的锆副产物同位素以满足预期临床要求的条件。 92Mo (γ, p2n)89Nb→89Zr 反应被发现最有希望用于光核生产。它可以提供最高纯度的锆放射性核素和最低量的锆稳定同位素。该方法的一个主要优点是能够使用天然钼靶材。