Poly(l-proline)-Stabilized Polypeptide Nanostructures via Ring-Opening Polymerization-Induced Self-Assembly (ROPISA),ACS Macro Letters

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Poly(l-proline)-Stabilized Polypeptide Nanostructures via Ring-Opening Polymerization-Induced Self-Assembly (ROPISA)
ACS Macro Letters ( IF 5.1 ) Pub Date : 2024-07-29 , DOI: 10.1021/acsmacrolett.4c00400
Ernesto Tinajero-Díaz ₁ , Nicola Judge ₁ , Bo Li ₁ , Thomas Leigh ₁ , Robert D Murphy ₁ , Paul D Topham ₂ , Matthew J Derry ₂ , Andreas Heise _{1,

3,

4}

Affiliation

Poly(proline) II helical motifs located at the protein–water interface stabilize the three-dimensional structures of natural proteins. Reported here is the first example of synthetic biomimetic poly(proline)-stabilized polypeptide nanostructures obtained by a straightforward ring-opening polymerization-induced self-assembly (ROPISA) process through consecutive N-carboxyanhydride (NCA) polymerization. It was found that the use of multifunctional 8-arm initiators is critical for the formation of nanoparticles. Worm-like micelles as well as spherical morphologies were obtained as confirmed by dynamic light scattering (DLS), transmission electron microscopy (TEM), and small angle X-ray scattering (SAXS). The loading of the nanostructures with dyes is demonstrated. This fast and open-vessel procedure gives access to amino acids-based nanomaterials with potential for applications in nanomedicine.

中文翻译：

通过开环聚合诱导自组装（ROPISA）的聚（L-脯氨酸）稳定的多肽纳米结构

位于蛋白质-水界面的聚（脯氨酸）II 螺旋基序稳定了天然蛋白质的三维结构。这里报道的是合成仿生聚脯氨酸稳定的多肽纳米结构的第一个例子，该纳米结构是通过连续的N-羧酸酐 (NCA) 聚合通过简单的开环聚合诱导自组装 (ROPISA) 过程获得的。研究发现，多功能八臂引发剂的使用对于纳米颗粒的形成至关重要。通过动态光散射 (DLS)、透射电子显微镜 (TEM) 和小角 X 射线散射 (SAXS) 证实，获得了蠕虫状胶束和球形形态。演示了纳米结构与染料的负载。这种快速且开放的容器程序可以获取具有纳米医学应用潜力的氨基酸纳米材料。

更新日期：2024-07-29

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