Biomarker profiles associated with reverse ventricular remodelling in patients with heart failure and a reduced ejection fraction: Insights from the echocardiographic substudy of the VICTORIA trial,European Journal of Heart Failure

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Biomarker profiles associated with reverse ventricular remodelling in patients with heart failure and a reduced ejection fraction: Insights from the echocardiographic substudy of the VICTORIA trial
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2024-07-30 , DOI: 10.1002/ejhf.3397
Jasper Tromp _{1,

2,

3} , Carolyn S P Lam ₂ , Wendimagegn Alemayehu ₄ , Christopher R de Filippi ₅ , Vojtěch Melenovský ₆ , Karen Sliwa ₇ , Yuri Lopatin ₈ , Juan Luis Arango ₉ , M Cecilia Bahit ₁₀ , Lothar Roessig ₁₁ , Christopher M O'Connor ₅ , Palak Shah ₅ , Cynthia M Westerhout ₄ , Adriaan A Voors _{3,

12} , Burkert Pieske ₁₃ , Paul W Armstrong ₄ ,

Affiliation

Saw Swee Hock School of Public Health National University of Singapore and National University of Singapore and National University Health System, Singapore, Singapore.
National Heart Centre Singapore, Duke-National University of Singapore, Singapore, Singapore.
Department of Cardiology, University Medical Centre Groningen, Groningen, The Netherlands.
University of Alberta, Canadian VIGOUR Centre, Edmonton, AB, Canada.
The Inova Center of Outcomes Research, Inova Heart and Vascular Institute, Falls Church, VA, USA.
Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic.
Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, Department of Medicine and Cardiology, University of Cape Town, Cape Town, South Africa.
Volgograd State Medical University, Regional Cardiology Centre Volgograd, Volgograd, Russian Federation.
Unidad de Cirugía Cardiovascular de Guatemala, Guatemala City, Guatemala.
INECO Neurociencias Oroño, Fundación INECO, Rosario, Argentina.
Bayer AG, Wuppertal, Germany.
University of Groningen, Groningen, The Netherlands.
Charité University Medicine, German Heart Center, Berlin, Germany.

Reverse ventricular remodelling, defined as a decrease in left ventricular end-systolic volume indexed to body surface area (LVESVI) or an increase in left ventricular ejection fraction (LVEF), is associated with improved clinical outcomes in patients with heart failure with reduced ejection fraction (HFrEF). However, the underlying pathophysiological mechanisms remain unclear.

中文翻译：

射血分数降低的心力衰竭患者与反向心室重塑相关的生物标志物谱：来自 VICTORIA 试验超声心动图子研究的见解

反向心室重塑，定义为与体表面积（LVESVI）相关的左心室收缩末期容积减少或左心室射血分数（LVEF）增加，与射血分数降低（HFrEF）心力衰竭患者的临床结局改善有关。然而，潜在的病理生理机制仍不清楚。

更新日期：2024-07-30

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