Pregnancy-related anxiety commonly occurs among first-time pregnant women, carrying an increased risk of harmful effects to both mother and the growing fetus or newborns. This study aims to assess the effectiveness of a Comprehensive Health-literacy And Relaxing Music (CHARM) intervention compared with two other stand-alone interventions (relaxing music–only intervention, comprehensive health literacy–only intervention) and a standard care group on pregnancy-related anxiety. We conducted an open-label, parallel four-arms, randomized controlled trial among 128 low-risk primigravid women, who were randomly allocated to one of the four groups (1:1:1:1). Women were assigned with a separate web-based link for the three interventions, which were provided for 4 weeks. The pregnancy-related anxiety was measured using the Pregnancy-Related Anxiety Questionnaire-Revised (PRAQ-R) assessed at baseline and post-intervention. After the 4-week intervention, a repeated-measures analysis of variance showed significant mean changes, and interaction effect between the groups on pregnancy-related anxiety levels ( F(3,124) = 5.6, p = .001, ηp2 = .12); CHARM intervention significantly reduced pregnancy-related anxiety levels in comparison with other three groups including the standard care group. The CHARM intervention was thus found to be effective in reducing pregnancy-related anxiety levels, and may be recommended for pregnant women for promoting their perinatal mental well-being.

中文翻译：

---

综合健康素养和放松音乐（CHARM）干预对低危初孕妇女妊娠相关焦虑的有效性：一项随机对照试验


与怀孕相关的焦虑通常发生在首次怀孕的女性中，这增加了对母亲以及正在成长的胎儿或新生儿产生有害影响的风险。本研究旨在评估综合健康素养和放松音乐（CHARM）干预措施与其他两种独立干预措施（仅放松音乐干预措施、仅综合健康素养干预措施）和标准护理组对妊娠的有效性进行比较。相关的焦虑。我们对 128 名低风险初孕妇女进行了一项开放标签、平行四组随机对照试验，这些妇女被随机分配到四组中的一组 (1:1:1:1)。妇女被分配了一个单独的网络链接来进行这三项干预措施，为期 4 周。使用在基线和干预后评估的妊娠相关焦虑问卷修订版（PRAQ-R）来测量与妊娠相关的焦虑。 4 周干预后，重复测量方差分析显示显着的平均变化以及各组之间对妊娠相关焦虑水平的交互作用 ( F(3,124) = 5.6, p = .001, η p 2 = .12);与包括标准护理组在内的其他三组相比，CHARM 干预显着降低了与妊娠相关的焦虑水平。因此，我们发现 CHARM 干预措施可有效降低与妊娠相关的焦虑水平，并可推荐给孕妇，以促进其围产期心理健康。