Puerarin Attenuates Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress and Suppresses Inflammation by Modulating the JNK and IKKβ/NF-κB Pathways in Epididymal White Adipose Tissue of Mice on a High-Fat Diet,Molecular Nutrition & Food Research

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Puerarin Attenuates Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress and Suppresses Inflammation by Modulating the JNK and IKKβ/NF-κB Pathways in Epididymal White Adipose Tissue of Mice on a High-Fat Diet
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-07-28 , DOI: 10.1002/mnfr.202400003
Jie Sun ₁ , Yan Liu ₁ , Jinjin Zhang ₂ , Huilin Shi ₁ , Rujiao Jiang ₁ , Meihua Guo ₁ , Yilin Liu ₃ , Bo Liu ₁ , Ning Wang ₁ , Rui Ma ₁ , Danna Zhang ₁ , Fang Zhang ₂ , Shujing Wang ₃ , Yingjie Wu _{1,

2}

Affiliation

Obesity is associated with insulin resistance (IR), which is characterized by endoplasmic reticulum (ER) stress in multiple organs. ER stress in adipose tissue causes metabolic disturbances and activates inflammatory signaling pathways. Puerarin, an isoflavone extracted from Pueraria lobata, exhibits antioxidant, anti-inflammatory, and antidiabetic effects. This study explores the potential mechanisms underlying puerarin's role in mitigating insulin resistance in high-fat diet (HFD)-induced obese mice.

中文翻译：

葛根素通过抑制内质网应激来减轻胰岛素抵抗，并通过调节高脂肪饮食小鼠附睾白色脂肪组织中的 JNK 和 IKKβ/NF-κB 通路来抑制炎症

肥胖与胰岛素抵抗（IR）有关，其特征是多个器官的内质网（ER）应激。脂肪组织中的 ER 应激会引起代谢紊乱并激活炎症信号通路。葛根素是一种从葛根中提取的异黄酮，具有抗氧化、抗炎和抗糖尿病作用。本研究探讨了葛根素在减轻高脂饮食（HFD）诱导的肥胖小鼠胰岛素抵抗中的作用的潜在机制。

更新日期：2024-07-28

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