Objective The objective is to determine the association and absolute risk of femoroacetabular impingement syndrome (FAIS) for the development of radiographic hip osteoarthritis (RHOA). Methods This is a nationwide, multicentre prospective cohort study (Cohort Hip and Cohort Knee) with 1002 individuals aged between 45 and 65 years. Hips without definitive RHOA (Kellgren-Lawrence (KL) grade≤1) at baseline and with anteroposterior pelvic radiographs at baseline and 10-year follow-up available (n=1386 hips) were included. FAIS was defined by the baseline presence of a painful hip, limited internal hip rotation≤25° and cam morphology defined by an alpha angle>60°. The outcomes were incident RHOA (KL grade≥2 or total hip replacement (THR)) and incident end-stage RHOA (KL≥3 or THR) within 10 years. Results Of the 1386 included hips (80% women; mean age 55.7±5.2 years), 21 hips fulfilled criteria for FAIS and 563 hips did not fulfil any of the FAIS criteria (reference group; no symptoms, no signs, no cam morphology). Within 10-year follow-up, 221 hips (38%) developed incident RHOA and 15 hips (3%) developed end-stage RHOA (including 9 hips with THR). Adjusted for sex, age and body mass index, FAIS with cam morphology resulted in an OR of 6.85 (95% CI 2.10 to 22.35) for incident RHOA and 47.82 (95% CI 12.51 to 182.76) for incident end-stage RHOA, compared with hips not having any FAIS criteria. The absolute risk of FAIS was 81% for incident RHOA and 33% for incident end-stage RHOA. Conclusion FAIS was strongly associated with the development of RHOA within 10 years. Although the baseline prevalence of FAIS was low, the high absolute risk of FAIS for RHOA warrants further studies to determine preventive strategies. Data are available on reasonable request. Data are available on reasonable request. The data underlying this article cannot be shared publicly due to legal reasons as well as the privacy of individuals that participated in the study.

中文翻译：

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中年人的股骨髋臼撞击综合征与 10 年内髋骨关节炎的发生密切相关：一项前瞻性队列研究 (CHECK)


目的 目的是确定股骨髋臼撞击综合征 (FAIS) 与放射学髋骨关节炎 (RHOA) 发展的关联性和绝对风险。方法 这是一项全国性、多中心前瞻性队列研究（髋关节队列和膝关节队列），共有 1002 名年龄在 45 岁至 65 岁之间的个体参与。基线时没有明确的 RHOA（Kellgren-Lawrence (KL) 等级≤1）、基线时有骨盆前后位 X 光片和 10 年随访的髋关节（n=1386 髋关节）被纳入其中。 FAIS 的定义是基线存在髋部疼痛、髋部内旋受限≤25° 以及 α 角>60° 定义的凸轮形态。结果是10年内发生的RHOA（KL等级≥2级或全髋关节置换术（THR））和终末期RHOA（KL≥3级或THR）。结果 在 1386 个髋关节中（80% 为女性；平均年龄 55.7±5.2 岁），21 个髋关节满足 FAIS 标准，563 个髋关节不满足任何 FAIS 标准（参考组；无症状、无体征、无凸轮形态） 。在 10 年的随访中，221 个髋关节 (38%) 发生了偶发性 RHOA，15 个髋关节 (3%) 发生了终末期 RHOA（包括 9 个髋关节发生 THR）。调整性别、年龄和体重指数后，与对照组相比，具有凸轮形态的 FAIS 对于突发 RHOA 的 OR 为 6.85（95% CI 2.10 至 22.35），对于突发终末期 RHOA 的 OR 为 47.82（95% CI 12.51 至 182.76）。髋关节没有任何 FAIS 标准。 RHOA 事件的 FAIS 绝对风险为 81%，终末期 RHOA 事件的 FAIS 绝对风险为 33%。结论 FAIS 与 10 年内 RHOA 的发生密切相关。尽管 FAIS 的基线患病率较低，但 RHOA 的 FAIS 绝对风险较高，值得进一步研究以确定预防策略。可根据合理要求提供数据。 可根据合理要求提供数据。由于法律原因以及参与研究的个人的隐私，本文所依据的数据无法公开共享。