Adipose tissue has been associated with knee osteoarthritis (KOA) pathogenesis, but the longitudinal changes in adipose tissue with KOA progression have not been carefully evaluated. This study aimed to determine if longitudinal changes of systemic and local adipose tissue is associated with radiographic progression of KOA. This case-control study used data from the Osteoarthritis Initiative (OAI) and included 315 cases (all the right knees with a minimum of Kellgren-Lawrence score (KL) of 0 and an increase of ≥ 1 KL from baseline to 48 months) and 315 controls matched by age, sex, race, and baseline KL. Cross sectional area of IPFP (IPFP CSA) and subcutaneous adipose tissue around the distal thigh (SCATthigh) were measured using MRI images at baseline and 24 months. Conditional logistic regression models were fitted to estimate associations of obesity markers, IPFP CSA, and SCATthigh with radiographic KOA progression. Mediation analysis was used to assess whether IPFP CSA or SCATthigh mediates the relationships between baseline BMI and radiographic KOA progression. 24-month changes of IPFP CSA (ΔIPFP CSA) and SCATthigh (ΔSCATthigh) were significantly greater in cases compared to controls, whereas Δ BMI and Δ abdominal circumference were similar in both groups during follow-up. Adjusted ORs for radiographic KOA progression were 9.299, 95% CI (5.357–16.141) per 1 SD increase of Δ IPFP CSA and 1.646, 95% CI (1.288–2.103) per 1 SD increase of Δ SCATthigh. ΔIPFP CSA mediated the association between baseline BMI and radiographic KOA progression (87%). Subjects with radiographic progression of KOA, had significant increases in IPFP CSA and subcutaneous adipose tissue while BMI and abdominal circumference remained stable. Additional studies are needed to confirm these associations.

中文翻译：

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膝骨关节炎放射学进展中的髌下脂肪垫大小和皮下脂肪：来自骨关节炎倡议的数据


脂肪组织与膝骨关节炎 (KOA) 发病机制相关，但脂肪组织随 KOA 进展的纵向变化尚未得到仔细评估。本研究旨在确定全身和局部脂肪组织的纵向变化是否与 KOA 的放射学进展相关。这项病例对照研究使用了骨关节炎倡议 (OAI) 的数据，纳入了 315 例病例（所有右膝的 Kellgren-Lawrence 评分 (KL) 最低为 0，并且从基线到 48 个月增加 ≥ 1 KL）和315 个对照按年龄、性别、种族和基线 KL 进行匹配。使用基线和 24 个月时的 MRI 图像测量 IPFP 的横截面积 (IPFP CSA) 和大腿远端周围的皮下脂肪组织 (SCATthigh)。拟合条件逻辑回归模型来估计肥胖标志物、IPFP CSA 和 SCATthigh 与放射学 KOA 进展的关联。中介分析用于评估 IPFP CSA 或 SCATthigh 是否介导基线 BMI 和放射学 KOA 进展之间的关系。与对照组相比，病例组的 24 个月 IPFP CSA (ΔIPFP CSA) 和 SCATthigh (ΔSCATthigh) 变化显着更大，而随访期间两组的 Δ BMI 和 Δ 腹围相似。放射照相 KOA 进展的调整 OR 为 Δ IPFP CSA 每增加 1 个 SD，调整后的 OR 为 9.299，95% CI (5.357–16.141)；Δ SCATthigh 每增加 1 个 SD，调整后的 OR 为 1.646，95% CI (1.288–2.103)。 ΔIPFP CSA 介导基线 BMI 和放射学 KOA 进展之间的关联 (87%)。放射学检查显示 KOA 进展的受试者的 IPFP CSA 和皮下脂肪组织显着增加，而 BMI 和腹围保持稳定。 需要更多的研究来证实这些关联。