Transient depletion of the gut microbiome by antibiotics in early life reduces systemic levels of the metabolite indole-3-propionic acid, which causes long-lasting mitochondrial damage to lung epithelial cells and increases susceptibility to airway inflammation in adult mice.

中文翻译：

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生命早期抗生素对肺上皮有持久影响


生命早期抗生素对肠道微生物组的短暂消耗降低了代谢物吲哚-3-丙酸的全身水平，这会导致肺上皮细胞线粒体长期损伤，并增加成年小鼠对气道炎症的易感性。