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Early life antibiotics have lasting effects on the lung epithelium
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-07-29 , DOI: 10.1038/s41577-024-01072-y Lucy Bird 1
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-07-29 , DOI: 10.1038/s41577-024-01072-y Lucy Bird 1
Affiliation
Transient depletion of the gut microbiome by antibiotics in early life reduces systemic levels of the metabolite indole-3-propionic acid, which causes long-lasting mitochondrial damage to lung epithelial cells and increases susceptibility to airway inflammation in adult mice.
中文翻译:
生命早期抗生素对肺上皮有持久影响
生命早期抗生素对肠道微生物组的短暂消耗降低了代谢物吲哚-3-丙酸的全身水平,这会导致肺上皮细胞线粒体长期损伤,并增加成年小鼠对气道炎症的易感性。
更新日期:2024-07-29
中文翻译:
生命早期抗生素对肺上皮有持久影响
生命早期抗生素对肠道微生物组的短暂消耗降低了代谢物吲哚-3-丙酸的全身水平,这会导致肺上皮细胞线粒体长期损伤,并增加成年小鼠对气道炎症的易感性。