Evaluation of effects of bisphenol analogs AF, S, and F on viability, proliferation, production of selected cancer-related factors, and expression of selected transcripts in Caov-3 human ovarian epithelial cell line,Food and Chemical Toxicology

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Evaluation of effects of bisphenol analogs AF, S, and F on viability, proliferation, production of selected cancer-related factors, and expression of selected transcripts in Caov-3 human ovarian epithelial cell line
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2024-07-24 , DOI: 10.1016/j.fct.2024.114889
Alzbeta Bujnakova Mlynarcikova ₁ , Sona Scsukova ₁

Affiliation

Bisphenol A (BPA) has been a substantial additive in plastics until the reports on its adverse effects have led to its restrictions and replacement. Monitoring studies document the increasing occurrence of bisphenol analogs, however, data on their effects and risks is still insufficient. Based on the indications that BPA might contribute to ovarian cancer pathogenesis, we examined effects of the analogs AF (BPAF), S (BPS) and F (BPF) (10–10 M) on the Caov-3 epithelial cancer cells, including the impact on cell viability, proliferation, oxidative stress, and production and expression of several factors and genes related to ovarian cancer. At environmentally relevant doses, bisphenols did not exert significant effects. At the highest concentration, BPAF caused varied alterations, including decreased cell viability and proliferation, caspase activation, down-regulation of and elevation of , , , and expressions. Only BPA (10 M) increased IL-6, IL-8 and VEGFA output by the Caov-3 cells. Each bisphenol induced generation of reactive oxygen species and decreased superoxide dismutase activity at the highest concentration. Although the effects were observed only in the supraphysiological doses, the results indicate that certain bisphenol analogs might affect several ovarian cancer cell characteristics and merit further investigation.

中文翻译：

评估双酚类似物 AF、S 和 F 对 Caov-3 人卵巢上皮细胞系中活力、增殖、选定癌症相关因子的产生以及选定转录物表达的影响

双酚 A (BPA) 一直是塑料中的重要添加剂，直到有关其不利影响的报道导致其受到限制和替代。监测研究记录了双酚类似物的出现不断增加，但有关其影响和风险的数据仍然不足。基于 BPA 可能与卵巢癌发病机制有关的迹象，我们检查了类似物 AF (BPAF)、S (BPS) 和 F (BPF) (10–10 M) 对 Caov-3 上皮癌细胞的影响，包括对细胞活力、增殖、氧化应激以及与卵巢癌相关的多种因子和基因的产生和表达的影响。在环境相关剂量下，双酚不会产生显着影响。在最高浓度时，BPAF 引起各种变化，包括细胞活力和增殖降低、半胱天冬酶激活、、、和表达的下调和升高。仅 BPA (10 M) 会增加 Caov-3 细胞的 IL-6、IL-8 和 VEGFA 输出。每种双酚在最高浓度下都会诱导活性氧的产生并降低超氧化物歧化酶的活性。尽管仅在超生理剂量下观察到效果，但结果表明某些双酚类似物可能会影响卵巢癌细胞的几种特征，值得进一步研究。

更新日期：2024-07-24

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