People with Parkinson’s disease (PWP) face critical challenges, including lack of access to neurological care, inadequate measurement and communication of motor symptoms, and suboptimal medication management and compliance. We have developed QDG-Care: a comprehensive connected care platform for Parkinson’s disease (PD) that delivers validated, quantitative metrics of all motor signs in PD in real time, monitors the effects of adjusting therapy and medication adherence and is accessible in the electronic health record. In this article, we describe the design and engineering of all components of QDG-Care, including the development and utility of the QDG Mobility and Tremor Severity Scores. We present the preliminary results and insights from an at-home trial using QDG-Care. QDG technology has enormous potential to improve access to, equity of, and quality of care for PWP, and improve compliance with complex time-critical medication regimens. It will enable rapid “Go-NoGo” decisions for new therapeutics by providing high-resolution data that require fewer participants at lower cost and allow more diverse recruitment.

帕金森病 (PWP) 患者面临着严峻的挑战，包括缺乏神经科护理、运动症状的测量和沟通不足以及药物管理和依从性不佳。我们开发了 QDG-Care：帕金森病 (PD) 的综合互联护理平台，可实时提供帕金森病所有运动体征的经过验证的定量指标，监测调整治疗和药物依从性的效果，并可在电子健康中访问记录。在本文中，我们描述了 QDG-Care 所有组件的设计和工程，包括 QDG 灵活性和震颤严重程度评分的开发和实用。我们展示了使用 QDG-Care 进行的家庭试验的初步结果和见解。 QDG 技术具有巨大的潜力，可以改善 PWP 护理的可及性、公平性和质量，并提高对复杂的时间紧迫的药物治疗方案的依从性。它将通过提供高分辨率数据，以更低的成本需要更少的参与者，并允许更多样化的招募，从而实现新疗法的快速“Go-NoGo”决策。