Continuous hemodynamic monitoring in a wearable means can play a crucial role in managing hypertension and preventing catastrophic cardiovascular events. In this study, we have described the fully wearable tonometric device, referred to as flexible adaptive sensing tonometry (FAST), which is capable of continuous and accurate monitoring of hemodynamic parameters within the medical-grade precision. In particular, the FAST system integrates a 1 × 8 unit array of highly sensitive and highly flexible iontronic sensing (FITS) with 1 mm spatial resolution and a closed-loop motion system. The flexible tonometric architecture has been used to determine the radial arterial position with high sensitivity and high conformability, which simplifies the biaxial searching process of the traditional applanation tonometry into a highly efficient uniaxial applanation while keeping the medical-precision assessments. Importantly, a self-calibration algorithm can be automatically implemented during the applanation process, from which the intra-arterial blood pressure wave can be continuously predicted within the medical-grade precision, and subsequently, multi-parametric hemodynamic analysis can be performed in real-time. Experimental validations on health volunteers have demonstrated that the FAST measurements are all within the required accuracy of the clinical standards for continuous pulse wave assessments, blood pressure monitoring as well as other key hemodynamic parameter evaluations. Therefore, the FAST system, by integrating the flexible iontronic sensing array, provides a real-time, medical-grade hemodynamic monitoring solution in a continuously wearable manner, from which remote patient-centered monitoring can be delivered with both medical precision and convenience.

可穿戴设备的连续血流动力学监测可以在控制高血压和预防灾难性心血管事件方面发挥至关重要的作用。在这项研究中，我们描述了完全可穿戴的眼压计设备，称为柔性自适应传感眼压计（FAST），它能够在医疗级精度内连续、准确地监测血流动力学参数。特别是，FAST系统集成了具有1毫米空间分辨率的高灵敏度和高灵活性离子电子传感（FITS）的1×8单元阵列和闭环运动系统。灵活的眼压计架构用于确定桡动脉位置，具有高灵敏度和高顺应性，将传统压平眼压计的双轴搜索过程简化为高效的单轴压平，同时保持医疗精度评估。重要的是，在压平过程中可以自动实现自校准算法，在医疗级精度内连续预测动脉内血压波，随后可以实时进行多参数血流动力学分析。时间。对健康志愿者的实验验证表明，FAST 测量结果均符合连续脉搏波评估、血压监测以及其他关键血流动力学参数评估的临床标准所需的准确性。因此，FAST系统通过集成灵活的离子电子传感阵列，以连续可穿戴的方式提供实时的医疗级血流动力学监测解决方案，从而可以实现以患者为中心的远程监测，同时实现医疗精度和便利性。