Obesity and its associated comorbidities constitute a serious and growing public health burden. Fractures affect a substantial proportion of people with obesity and result from reduced bone strength relative to increased mechanical loading, together with an increased risk of falls. Factors contributing to fractures in people with obesity include adverse effects of adipose tissue on bone and muscle and, in many people, the coexistence of type 2 diabetes. Strategies to reduce weight include calorie-restricted diets, exercise, bariatric surgery, and pharmacological interventions with GLP-1 receptor agonists. However, although weight loss in people with obesity has many health benefits, it can also have adverse skeletal effects, with increased bone loss and fracture risk. Priorities for future research include the development of effective approaches to reduce fracture risk in people with obesity and the investigation of the effects of GLP-1 receptor agonists on bone loss resulting from weight reduction.

中文翻译：

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促进减肥干预前后肥胖成人的骨骼健康


肥胖及其相关合并症构成了严重且不断增长的公共卫生负担。骨折影响了很大一部分肥胖症患者，这是由于相对于机械负荷增加而言，骨骼强度降低，以及跌倒风险增加的结果。导致肥胖症患者骨折的因素包括脂肪组织对骨骼和肌肉的不利影响，以及许多人同时存在 2 型糖尿病。减轻体重的策略包括限制热量饮食、运动、减肥手术和使用 GLP-1 受体激动剂的药物干预。然而，尽管肥胖患者的体重减轻对健康有很多好处，但它也可能对骨骼产生不利影响，增加骨质流失和骨折风险。未来研究的重点包括开发降低肥胖患者骨折风险的有效方法，以及研究 GLP-1 受体激动剂对减肥引起的骨质流失的影响。