Perfluorobutane sulfonate is a short-chain PFAS that is a less toxic replacement for the rather more toxic long-chain perfluorooctane sulfonate. PFBS is widespread in the environment and has raised environmental and health concerns. The study goal was to investigate whether dietary ingestion of PFBS would induce hepatic damage. Sprague-Dawley rats were assigned to three PFBS treatment groups for 11 weeks followed by clinical markers analyses in the serum and liver. There was a significant increase in liver and body weights of PFBS rats. Total antioxidant capacity was significantly reduced in the PFBS-treated group. ALT levels increased based on concentration ingested. Close to 1000 gene transcripts were differentially expressed. Further, transmembrane transport and oxidation-reduction processes were the most up-regulated biological processes. Inflammatory genes were up-regulated in the exposed group and those associated with oxidative damage were down-regulated. In conclusion, PFBS ingestion produced mild effects in the liver of Sprague Dawley rats.

中文翻译：

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Sprague Dawley 大鼠对膳食全氟丁磺酸 (PFBS) 摄入的反应的肝脏转录组学评估


全氟丁烷磺酸是一种短链 PFAS，是毒性较大的长链全氟辛烷磺酸的毒性较小的替代品。 PFBS 在环境中广泛存在，引起了环境和健康问题。该研究的目的是调查饮食中摄入 PFBS 是否会引起肝损伤。 Sprague-Dawley 大鼠被分配到三个 PFBS 治疗组，为期 11 周，然后进行血清和肝脏的临床标志物分析。 PFBS大鼠的肝脏和体重显着增加。 PFBS 处理组的总抗氧化能力显着降低。 ALT 水平随着摄入浓度的增加而增加。近1000个基因转录本存在差异表达。此外，跨膜运输和氧化还原过程是最上调的生物过程。暴露组的炎症基因上调，而与氧化损伤相关的基因下调。总之，摄入 PFBS 对 Sprague Dawley 大鼠的肝脏产生了轻微影响。