Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis,Gastroenterology

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Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis
Gastroenterology ( IF 25.7 ) Pub Date : 2024-07-22 , DOI: 10.1053/j.gastro.2024.07.016
Yuan Chen ₁ , Xinpeng Yin ₁ , Ruiyuan Xu ₁ , Rexiati Ruze ₁ , Jianlu Song ₁ , Chenxue Yin ₁ , Chenglin Hu ₁ , Chengcheng Wang ₂ , Qiang Xu ₃ , Yupei Zhao ₃

Affiliation

Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Key Laboratory of Research in Pancreatic Tumor, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
Key Laboratory of Research in Pancreatic Tumor, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China; National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Beijing, People's Republic of China; Institute of Clinical Medicine, Peking Union Medical College Hospital, Beijing, People's Republic of China.
Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Key Laboratory of Research in Pancreatic Tumor, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China; National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Beijing, People's Republic of China.

The pancreas is composed of endocrine and exocrine parts, and its interlacing structure indicates potential interaction between endocrine and exocrine cells. Although the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has been well characterized, the role of pancreatic endocrine cells during carcinogenesis is relatively understudied.

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