ObjectiveTo determine the changes in health‐related quality of life (HRQoL) and sleep quality following a supervised combined exercise (EX) program compared to a Treatment‐As‐Usual (TAU) and to analyze the relationship between the differences in cardiorespiratory fitness (CRF) and HRQoL domains in people with schizophrenia (SZ).MethodsThe SZ (n = 112, 41.3 ± 10.4 year) was randomly assigned into a TAU control group (n = 53) or EX‐group (n = 59, 3 days/week). The 36‐item Short‐Form Health Survey questionnaire assessed HRQoL and the sleep quality analysis (accelerometry).ResultsAfter the intervention (20 weeks), physical functioning (∆ = 12.9%), general health (∆ = 15.3%), mental health (∆ = 8.3%), physical component summary (PCS) (∆ = 5.1%), and sleep efficiency (∆ = 1.9%) increased (p < 0.05) in the EX, with no significant changes in the TAU for any domains studied. There were significant differences between groups whose EX showed improvements (p < 0.05) compared to TAU in physical functioning, general health, PCS, and sleep efficiency. A greater CRF was associated with better values in physical functioning, role‐physical, bodily pain, general health, vitality, and PCS after the exercise program in SZ.ConclusionsA 20‐week supervised combined exercise intervention program for SZ increased sleep efficiency and physical functioning, general and mental health, and PCS scores. This could lead to a critical HRQoL change from how they were to how they should be.Trial Registration: ClinicalTrials.gov identifier: NCT03509597

中文翻译：

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我们过去和应该做的，成人精神分裂症患者的联合运动训练：CORTEX-SP 研究第二部分


目的 确定与常规治疗 (TAU) 相比，监督下综合运动 (EX) 计划后健康相关生活质量 (HRQoL) 和睡眠质量的变化，并分析心肺健康 (CRF) 差异之间的关系) 和精神分裂症患者 (SZ) 的 HRQoL 域。方法SZ ( n = 112, 41.3 ± 10.4 年）被随机分配到 TAU 对照组（ n = 53) 或 EX-group ( n = 59，每周 3 天）。 36 项简短健康调查问卷评估了 HRQoL 和睡眠质量分析（加速测量）。结果干预后（20 周），身体功能（ Δ = 12.9%），总体健康状况（ Δ = 15.3%），心理健康（ Δ = 8.3%), 物理成分汇总 (PCS) ( Δ = 5.1%）和睡眠效率（ Δ = 1.9%）增加（ p < 0.05) 在 EX 中，对于所研究的任何域，TAU 没有显着变化。 EX 显示改善的组之间存在显着差异（ p < 0.05) 与 TAU 在身体机能、总体健康状况、PCS 和睡眠效率方面相比。在 SZ 进行锻炼计划后，较高的 CRF 与身体机能、角色身体、身体疼痛、总体健康、活力和 PCS 方面的数值更好相关。结论 SZ 的 20 周监督联合运动干预计划提高了睡眠效率和身体机能、一般健康和心理健康以及 PCS 分数。这可能会导致 HRQoL 从原来的状态转变为应有的状态。 试验注册：ClinicalTrials.gov 标识符：NCT03509597