As we age, our cells acquire DNA mutations, resulting in cell-to-cell genomic heterogeneity. We characterized the landscape of mitochondrial DNA (mtDNA) heterogeneity in healthy human cells. Our observations provide deeper insight into the frequency of new mitochondrial mutations and the mechanisms that propagate low-level mutations in mtDNA over a lifetime.

中文翻译：

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揭示人类细胞 mtDNA 突变的起源和力量


随着年龄的增长，我们的细胞会发生 DNA 突变，从而导致细胞间的基因组异质性。我们描述了健康人类细胞中线粒体 DNA (mtDNA) 异质性的特征。我们的观察提供了对线粒体新突变的频率以及一生中 mtDNA 低水平突变传播机制的更深入的了解。