Sports Medicine ( IF 9.3 ) Pub Date : 2024-07-26 , DOI: 10.1007/s40279-024-02079-0 Kevin Bischof 1, 2 , Anna Maria Moitzi 2, 3 , Savvas Stafilidis 4 , Daniel König 1, 2, 3
|
Introduction
Over the past decade, collagen peptide (CP) supplements have received considerable attention in sports nutrition research. These supplements have shown promising results in improving personal health, enhancing athletic performance, and preventing injuries in some but not all studies.
Objective
A systematic review and meta-analysis of randomized controlled trials (RCTs) has been conducted to investigate the effects of long-term daily collagen peptide (CP) supplementation on strength, musculotendinous adaptation, functional recovery, and body composition in healthy adults, both with and without concurrent exercise interventions over several weeks.
Methods
The PRISMA with PERSiST guidelines were followed for this systematic literature review, which was conducted in December 2023 using PubMed, Scopus, CINAHL, and SPORTDiscus databases. Eligible studies included healthy, normal to overweight adults over 17 years of age who engaged in exercise and daily collagen peptide (CP) supplementation for a minimum of 8 weeks (except one 3-week trial only included for maximal strength). Studies examining recovery-related outcomes were also eligible if they included a 1-week supplementation period without exercise. Methodological study quality was assessed using the PEDro scale. A random-effects model with standardized mean differences (SMD) of change scores was chosen to calculate overall effect sizes.
Results
Nineteen studies comprising 768 participants were included in both the systematic review and meta-analysis. Results indicate statistically significant effects in favor of long-term CP intake regarding fat-free mass (FFM) (SMD 0.48, p < 0.01), tendon morphology (SMD 0.67, p < 0.01), muscle architecture (SMD 0.39, p < 0.01), maximal strength (SMD 0.19, p < 0.01), and 48 h recovery in reactive strength following exercise-induced muscle damage (SMD 0.43, p = 0.045). The GRADE approach revealed a moderate certainty of evidence for body composition, a very low certainty for tendon morphology and mechanical properties, and a low certainty for the remaining.
Conclusion
This systematic review and meta-analysis represents the first comprehensive investigation into the effects of long-term CP supplementation combined with regular physical training on various aspects of musculoskeletal health in adults. The findings indicate significant, though of low to moderate certainty, evidence of improvements in fat-free mass (FFM), tendon morphology, muscle mass, maximal strength, and recovery in reactive strength following exercise-induced muscle damage. However, further research is required to fully understand the mechanisms underlying these effects, particularly regarding tendon mechanical properties and short-term adaptations to collagen peptide (CP) intake without exercise, as observed in recovery outcomes. Overall, CP supplementation appears promising as a beneficial adjunct to physical training for enhancing musculoskeletal performance in adults.
Open Science Framework (Registration DOI: https://doi.org/10.17605/OSF.IO/WCF4Y).
中文翻译：
胶原蛋白肽补充剂联合长期体育锻炼对健康成人力量、肌肉肌腱重塑、功能恢复和身体成分的影响：荟萃分析的系统评价
介绍
在过去的十年中，胶原蛋白肽 （CP） 补充剂在运动营养研究中受到了相当大的关注。在一些但不是全部研究中，这些补充剂在改善个人健康、提高运动表现和预防受伤方面显示出有希望的结果。
目的
对随机对照试验 （RCT） 进行了系统评价和荟萃分析，以研究长期每日补充胶原蛋白肽 （CP） 对健康成人力量、肌腱适应、功能恢复和身体成分的影响，包括有和没有几周内同时进行运动干预。
方法
本系统文献综述遵循 PRISMA with PERSiST 指南，该文献综述于 2023 年 12 月使用 PubMed、Scopus、CINAHL 和 SPORTDiscus 数据库进行。符合条件的研究包括17岁以上的健康、正常至超重的成年人，他们进行运动并每天补充胶原蛋白肽（CP）至少8周（除了一项为期3周的试验，仅包括最大强度）。如果检查恢复相关结局的研究包括 1 周无运动的补充期，则也符合条件。使用 PEDro 量表评估方法学研究质量。选择具有变化评分标准化平均差 （SMD） 的随机效应模型来计算总体效应大小。
结果
系统评价和荟萃分析纳入了 19 项研究，涉及 768 名参与者。结果表明，长期 CP 摄入对无脂肪质量 （FFM） （SMD 0.48，p < 0.01）、肌腱形态 （SMD 0.67，p < 0.01）、肌肉结构 （SMD 0.39，p < 0.01）、最大力量 （SMD 0.19，p < 0.01） 和运动引起的肌肉损伤后 反应强度恢复 48 小时 （SMD 0.43， p ） 的影响具有统计学意义= 0.045）。GRADE 方法显示身体成分的证据质量为中等，肌腱形态和机械性能的证据质量极低，其余证据的质量为低。
结论
本系统评价和荟萃分析代表了对长期 CP 补充剂结合定期体育锻炼对成人肌肉骨骼健康各个方面影响的首次全面调查。研究结果表明，运动引起的肌肉损伤后无脂肪质量 （FFM）、肌腱形态、肌肉质量、最大力量和反应力量恢复的显著（尽管质量为低到中等）证据表明有所改善。然而，需要进一步的研究来充分了解这些影响背后的机制，特别是关于肌腱机械特性和在不运动的情况下对胶原蛋白肽 （CP） 摄入的短期适应，如在恢复结果中观察到的那样。总体而言，CP 补充剂似乎很有希望作为体育训练的有益辅助手段，以增强成人的肌肉骨骼表现。
开放科学框架（注册 DOI：https://doi.org/10.17605/OSF.IO/WCF4Y）。
京公网安备 11010802027423号