3D Printed Drug Delivery Systems in Action–Magnetic Resonance Imaging and Relaxometry for Monitoring Mass Transport Phenomena,ACS Applied Materials & Interfaces

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3D Printed Drug Delivery Systems in Action–Magnetic Resonance Imaging and Relaxometry for Monitoring Mass Transport Phenomena
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2024-07-26 , DOI: 10.1021/acsami.4c08501
Ewelina Baran ₁ , Artur Birczyński ₁ , Bartłomiej Milanowski _{2,

3} , Jolanta Klaja ₄ , Piotr Nowak ₅ , Przemysław Dorożyński ₆ , Piotr Kulinowski ₁

Affiliation

The hypothesis of the study was that (1) 3D printed drug delivery systems (DDS) could be characterized in situ during drug release using NMR/MRI techniques in terms of mass transport phenomena description (interfacial phenomena), particularly for systems dealing with two mobile phases (e.g., water and low molecular weight liquid polymer); (2) consequently, it could be possible to deduce how these interfacial mass transport phenomena influence functional properties of 3D printed DDS. Matrix drug delivery systems, prepared using masked stereolithography (MSLA), containing poly(ethylene glycol) diacrylate (PEGDA) and low molecular weight polyethylene glycol (PEG) with ropinirole hydrochloride (RH) were studied as example formulations. The PEGDA to PEG (mobile phase) concentration ratio influenced drug release. It was reflected in spatiotemporal changes in parametric T₂ relaxation time (T₂) and amplitude (A) images obtained using magnetic resonance imaging (MRI) and T₁-T₂ relaxation time correlations obtained using low-field time-domain nuclear magnetic resonance (LF TD NMR) relaxometry during incubation in water. For most of the tested formulations, two signal components related to PEG and water were assessed in the hydrated matrices by MRI relaxometry (parametric T₂/A images). The PEG component faded out due to outward PEG diffusion and was gradually replaced by the water component. Both components spatially and temporally changed their parameters, reflecting evolving water–polymer interactions. The study shows that dynamic phenomena related to bidirectional mass transport can be quantified in situ using NMR and MRI techniques to gain insight into drug release mechanisms from 3D printed DDS systems.

中文翻译：

3D 打印药物输送系统的实际应用——磁共振成像和松弛测量法用于监测质量传递现象

该研究的假设是：(1) 3D 打印药物递送系统 (DDS) 可以在药物释放过程中使用 NMR/MRI 技术在质量传输现象描述（界面现象）方面进行原位表征，特别是对于处理两个移动的系统相（例如水和低分子量液体聚合物）； (2) 因此，可以推断出这些界面传质现象如何影响 3D 打印 DDS 的功能特性。使用掩模立体光刻 (MSLA) 制备的基质药物递送系统作为示例制剂进行了研究，该系统含有聚乙二醇二丙烯酸酯 (PEGDA) 和低分子量聚乙二醇 (PEG) 以及盐酸罗匹尼罗 (RH)。 PEGDA 与 PEG（流动相）浓度比影响药物释放。它反映在使用磁共振成像（MRI）获得的参数T ₂弛豫时间（T ₂ ）和振幅（A）图像以及使用低场时域核磁共振获得的T ₁ -T ₂弛豫时间相关性的时空变化中。 (LF TD NMR) 水中孵育期间的弛豫测量。对于大多数测试的制剂，通过 MRI 弛豫测量（参数 T ₂ /A 图像）评估水合基质中与 PEG 和水相关的两个信号成分。由于PEG向外扩散，PEG成分逐渐消失，并逐渐被水成分取代。两种成分在空间和时间上都改变了它们的参数，反映了不断变化的水-聚合物相互作用。研究表明，可以使用 NMR 和 MRI 技术对与双向质量传输相关的动态现象进行原位量化，以深入了解 3D 打印 DDS 系统的药物释放机制。

更新日期：2024-07-26

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