Aims To assess the association between statin use and cataract surgery according to different statin treatment durations in patients with different cardiovascular risk profiles. Methods and results We performed a nested case–control study using Danish registries, covering the period from 1 January 1996 to 31 December 2020. We defined cases as surgically treated cataract patients, matched in a 1:1 ratio by sex and age with controls not undergoing cataract surgery. The exposure of interest was statin use in different durations (1, 5 and 10 years) compared with never use of statins. Conditional logistic regression provided adjusted HRs and corresponding 95% CIs in subgroups defined by established atherosclerotic cardiovascular disease, diabetes, hypertension and individuals without these comorbidities. We identified 505 150 cataract surgery cases and found no increased HR of cataract surgery with statin treatment at any duration in any of the subgroups with established atherosclerotic cardiovascular disease, diabetes or hypertension. Conclusion Our findings do not support a possible association between long-term statin use and cataract in patients with established atherosclerotic cardiovascular disease, diabetes or hypertension. Although we found an association between statin use and cataract in individuals without these comorbidities, increasing durations of statin use did not yield higher cataract surgery rates. Data are available on reasonable request. We are able to provide the data used for conducting the present study on reasonable request as this requires special access to Statistics Denmark.

中文翻译：

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长期使用他汀类药物与白内障手术之间的关联：一项针对 505 105 名白内障手术患者的全国性研究


目的 根据具有不同心血管风险特征的患者的不同他汀类药物治疗持续时间，评估他汀类药物使用与白内障手术之间的关联。方法和结果我们利用丹麦登记处进行了一项巢式病例对照研究，涵盖1996年1月1日至2020年12月31日。我们将病例定义为接受手术治疗的白内障患者，按性别和年龄按1:1的比例进行匹配，对照组未接受手术治疗。正在接受白内障手术。感兴趣的暴露是不同持续时间（1 年、5 年和 10 年）使用他汀类药物与从未使用他汀类药物的比较。条件 Logistic 回归在由已确定的动脉粥样硬化性心血管疾病、糖尿病、高血压和没有这些合并症的个体定义的亚组中提供了调整后的 HR 和相应的 95% CI。我们确定了 505 150 例白内障手术病例，发现在患有动脉粥样硬化性心血管疾病、糖尿病或高血压的任何亚组中，在任何时间段内接受他汀类药物治疗的白内障手术 HR 均未增加。结论 我们的研究结果不支持患有动脉粥样硬化性心血管疾病、糖尿病或高血压的患者长期使用他汀类药物与白内障之间可能存在的关联。尽管我们发现在没有这些合并症的个体中，他汀类药物的使用与白内障之间存在关联，但增加他汀类药物的使用时间并不会提高白内障手术率。可根据合理要求提供数据。我们能够根据合理要求提供用于进行本研究的数据，因为这需要特别访问丹麦统计局。