Splice-modifying drug mechanisms,Nature Chemical Biology

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Splice-modifying drug mechanisms
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2024-07-26 , DOI: 10.1038/s41589-024-01678-2
Jorge Herrero-Vicente _{1,

2} , Douglas L Black ₃ , Juan Valcárcel _{1,

2,

4}

Affiliation

A new study combines massively parallel assays, transcriptomics and biophysical modeling to provide a framework for analyzing the effects of compounds that modulate pre-mRNA splicing. The results lend important insights into the mechanisms of drug action and facilitate the design of splicing therapies.

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