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Hypotoxic amphiphilic polymers with high fluoride content as oxygen carriers enhance photodynamic therapy against hypoxic tumors
Polymer Chemistry ( IF 4.1 ) Pub Date : 2024-07-26 , DOI: 10.1039/d4py00598h Jun-an Zhang 1 , Jiang-feng Sheng 2 , David Haddleton 3 , Paul Wilson 3 , Yong-jie Mo 1 , Hong-li Li 1 , Hong-lei Zhao 4 , Lin-hua Zhu 1, 3 , Chun-yan Dai 1, 3 , Lin-lu Zhao 5
Polymer Chemistry ( IF 4.1 ) Pub Date : 2024-07-26 , DOI: 10.1039/d4py00598h Jun-an Zhang 1 , Jiang-feng Sheng 2 , David Haddleton 3 , Paul Wilson 3 , Yong-jie Mo 1 , Hong-li Li 1 , Hong-lei Zhao 4 , Lin-hua Zhu 1, 3 , Chun-yan Dai 1, 3 , Lin-lu Zhao 5
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Photodynamic therapy (PDT) eradicates cancer cells by transforming tumor oxygen into highly reactive singlet oxygen (1O2) through a photosensitizer. However, pre-existing hypoxia within tumors and oxygen consumption during PDT can cause insufficient oxygen supply, hence hindering the effectiveness of this treatment modality. Fluorides, renowned for their excellent biocompatibility and oxygen affinity, have been widely applied in medical environments as carriers. In this study, a hypotoxic amphiphilic fluorinated polymer (PEGAF) was synthesized using polyethylene glycol methyl ether acrylate (PEGA) and perfluorooctyl acrylate (PFOEA) as monomers through the atomic transfer radical polymerization (ATRP) technology and used as carriers for oxygen and the photosensitizer chlorin e6 (Ce6). Experimental results demonstrated that PEGAF@Ce6-O2 substantially improved the hypoxic microenvironment of tumors and significantly inhibited tumor growth, markedly enhancing the outcome compared to sole PDT application. This study proposes a new strategy for enhancing the efficacy of PDT.
中文翻译：
具有高氟化物含量的低毒两亲性聚合物作为氧载体增强针对缺氧肿瘤的光动力疗法
光动力疗法（PDT）通过光敏剂将肿瘤氧转化为高活性单线态氧（ 1 O 2 ）来消灭癌细胞。然而，肿瘤内预先存在的缺氧和PDT期间的氧气消耗可能会导致氧气供应不足，从而阻碍这种治疗方式的有效性。氟化物以其优异的生物相容性和氧亲和力而闻名，作为载体广泛应用于医疗环境中。本研究以聚乙二醇甲醚丙烯酸酯（PEGA）和丙烯酸全氟辛酯（PFOEA）为单体，通过原子转移自由基聚合（ATRP）技术合成了一种低毒两亲性氟化聚合物（PEGAF），并用作氧和光敏剂的载体二氢卟酚 e6 (Ce6)。实验结果表明，PEGAF@Ce6-O 2 显着改善了肿瘤的缺氧微环境，并显着抑制肿瘤生长，与单独 PDT 应用相比，显着提高了治疗效果。这项研究提出了一种增强 PDT 疗效的新策略。
更新日期：2024-07-26
中文翻译：
具有高氟化物含量的低毒两亲性聚合物作为氧载体增强针对缺氧肿瘤的光动力疗法
光动力疗法（PDT）通过光敏剂将肿瘤氧转化为高活性单线态氧（ 1 O 2 ）来消灭癌细胞。然而，肿瘤内预先存在的缺氧和PDT期间的氧气消耗可能会导致氧气供应不足，从而阻碍这种治疗方式的有效性。氟化物以其优异的生物相容性和氧亲和力而闻名，作为载体广泛应用于医疗环境中。本研究以聚乙二醇甲醚丙烯酸酯（PEGA）和丙烯酸全氟辛酯（PFOEA）为单体，通过原子转移自由基聚合（ATRP）技术合成了一种低毒两亲性氟化聚合物（PEGAF），并用作氧和光敏剂的载体二氢卟酚 e6 (Ce6)。实验结果表明，PEGAF@Ce6-O 2 显着改善了肿瘤的缺氧微环境，并显着抑制肿瘤生长，与单独 PDT 应用相比，显着提高了治疗效果。这项研究提出了一种增强 PDT 疗效的新策略。
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