A nickel-catalysed C-N cross-coupling of organoboronic acids and isoxazoles has been established for the efficient synthesis of (Z) N-aryl β-enamino esters. 5-Alkoxy/phenoxy isoxazoles serves as reliable aminating reagents in this transformation through N-O bond cleavage. A wide range of N-aryl β-enamino esters (32 examples upto 93% yield) with different functional groups were synthesized through this method under mild reaction condition.

中文翻译：

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镍催化有机硼酸和异恶唑的 C-N 交叉偶联


建立了镍催化的有机硼酸和异恶唑的 C-N 交叉偶联，用于有效合成 (Z) N-芳基 β-烯胺酯。 5-烷氧基/苯氧基异恶唑在此通过 N-O 键断裂的转化中充当可靠的胺化试剂。通过该方法在温和的反应条件下合成了多种具有不同官能团的N-芳基β-烯胺酯（32个实例，收率高达93%）。