The photoinduced decarboxylative radical cascade alkylation/cyclization strategy of diverse benzimidazole containing unactivated alkene moieties towards synthesis of polycyclic benzimidazoles via ligand-to-metal-charge-transfer (LMCT) has been developed. Specifically, the reaction initiates the decarboxylation of alkyl carboxylic acids through light-induced charge transfer from the ligand to iron, resulting in the formation of alkyl radical centers. Moreover, the protocol has prominent features such as the broad range of substrate scope, high regioselectivity, mild reaction conditions, operational simplicity and readily available air acted as the sole oxidant.

中文翻译：

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通过配体到铁电荷转移苯并咪唑衍生物与脂肪族羧酸的光诱导脱羧自由基级联烷基化/环化


开发了含有未活化烯烃部分的多种苯并咪唑的光诱导脱羧自由基级联烷基化/环化策略，通过配体到金属电荷转移（LMCT）合成多环苯并咪唑。具体来说，该反应通过光诱导的电荷从配体转移到铁来引发烷基羧酸的脱羧，从而形成烷基自由基中心。此外，该方案还具有底物范围广、区域选择性高、反应条件温和、操作简单、可用空气作为唯一氧化剂等突出特点。