Brain malformations represent a heterogeneous group of abnormalities of neural morphogenesis, often associated with aberrations of neuronal connectivity and brain volume. Prenatal detection of brain malformations requires a clear understanding of embryology and developmental morphology through the various stages of gestation. This expert panel review is written with the central aim of providing an easy-to-understand road map to improve prenatal detection and characterization of structural malformations based on the current understanding of normal and aberrant brain development. For every developmental stage, the utility of each available neuroimaging modality, including prenatal multiplanar neuro sonography, anatomical MRI and advanced MRI techniques, as well as further insights from post-mortem imaging, has been highlighted.

中文翻译：

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神经影像学上脑畸形的产前评估：专家组评价


脑畸形代表了一组异质性的神经形态发生异常，通常与神经元连接和脑容量的畸变有关。脑畸形的产前检测需要清楚地了解妊娠各个阶段的胚胎学和发育形态。本专家小组审查的核心目的是提供一个易于理解的路线图，以根据当前对正常和异常大脑发育的理解，改进产前检测和结构畸形的表征。对于每个发育阶段，每种可用的神经影像学模式的效用，包括产前多平面神经超声检查、解剖 MRI 和先进的 MRI 技术，以及来自死后成像的进一步见解，都得到了强调。