Mendelian randomisation supports no evidence of the association between asthma and coronary heart disease in East Asians,European Respiratory Journal

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Mendelian randomisation supports no evidence of the association between asthma and coronary heart disease in East Asians
European Respiratory Journal ( IF 16.6 ) Pub Date : 2024-07-25 , DOI: 10.1183/13993003.00628-2024
Jiawen Lu ₁ , Zhenqian Wang ₂

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Extract

We were very interested to read the recent paper by Valencia-Hernández et al. [1], who conducted a prospective study of 1 522 910 UK individuals and a Mendelian randomisation (MR) study. They discovered that asthma was not a risk factor for coronary heart disease (CHD) among European individuals [1]. Nevertheless, their finding was restricted to European individuals and may not be generalisable to other ethnicities. For instance, a cross-sectional study involving 173 209 Korean individuals reported an association between asthma and a higher risk of ischaemic heart disease [2]. Similarly, a prospective study in China with 38 840 participants found a link between asthma and an increased risk of acute coronary syndrome, a type of CHD [3].

更新日期：2024-07-25

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