Mobile element insertions affect human pigmentation and skin cancer risk,Nature Genetics

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Mobile element insertions affect human pigmentation and skin cancer risk
Nature Genetics ( IF 31.7 ) Pub Date : 2024-07-24 , DOI: 10.1038/s41588-024-01849-w
Jeffrey M Kidd ₁

Affiliation

Nearly 50% of the sequence of mammalian genomes is derived from mobile elements that inserted into the genome over millions of years of evolution. A recent mobile element insertion, found only in some individuals with European genetic ancestry, contributes to decreased skin pigmentation and increased sunburn frequency and skin cancer risk.

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