Early intervention trials have been initiated for the precursor disease smoldering myeloma (SMM). A recent study showed that genomic complexity varies widely among treated high-risk SMM patients and is associated with response to triplet therapy, suggesting that established clinical risk scores often fail to discriminate between stable and aggressive disease.

中文翻译：

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定义真正的高风险冒烟性骨髓瘤的困难


针对前驱疾病冒烟性骨髓瘤（SMM）的早期干预试验已经启动。最近的一项研究表明，接受治疗的高风险 SMM 患者的基因组复杂性差异很大，并且与三联疗法的反应相关，这表明既定的临床风险评分通常无法区分稳定疾病和侵袭性疾病。