This Letter reports on the processing, mechanical properties, electrochemical performance, and toxicity behavior of a multiprincipal element Ti35Nb30Zr29Mo3Ta3 alloy. The recovered centimeter-sized cubes or parallelepipeds were polished before analysis. It was found that the homogeneity and yield stress of the alloys get increased when higher volumetric energy densities are applied during processing. The synthesized alloys also exhibited a Young modulus closer to those of bones than those usually reported on the conventional orthopedic metals (60–80 GPa for this alloy against 110 and 4–30 GPa for the Ti-6Al-4V and bone, respectively). The electrochemical corrosion assays performed at 25 and 37 °C, in sodium chloride (NaCl, 0.1 M), deoxygenated high glucose Dulbecco's Modified Eagle Medium (DMEM), and deoxygenated DMEM implemented with fetal bovine serum showed corrosion potentials (Ecorr) ranged in the order NaCl(25 °C) ≈ DMEM + PBS(37 °C) > DMEM(37 °C) and impedances much larger in the DMEM and DMEM + PBS media than in NaCl. Finally, pre-osteoblasts cells cultured in the medium conditioned by the alloy did not evidence cytotoxicity effect, because no effects on the cell proliferation and morphology were observed. These data suggest the biocompatibility of this alloy, indicating no acute toxicity, which is a prerequisite for the integration of an alloy as a bioimplant.

中文翻译：

---

用于医疗植入物的 Ti35Nb30Zr29Mo3Ta3 多主元合金的 L-PBF 加工和表征


本信报告了多主元 Ti35Nb30Zr29Mo3Ta3 合金的加工、机械性能、电化学性能和毒性行为。回收的厘米大小的立方体或平行六面体在分析前进行抛光。研究发现，当加工过程中应用更高的体积能量密度时，合金的均匀性和屈服应力会增加。合成合金还表现出比通常报道的传统矫形金属的杨氏模量更接近骨骼的杨氏模量（该合金的杨氏模量为 60-80 GPa，而 Ti-6Al-4V 和骨骼的杨氏模量分别为 110 和 4-30 GPa）。在 25 和 37 °C、氯化钠（NaCl，0.1 M）、脱氧高葡萄糖 Dulbecco 改良 Eagle 培养基 (DMEM) 和使用胎牛血清的脱氧 DMEM 中进行的电化学腐蚀测定显示，腐蚀电位 (Ecorr) 范围在顺序 NaCl(25 °C) ≈ DMEM + PBS(37 °C) > DMEM(37 °C)，并且 DMEM 和 DMEM + PBS 介质中的阻抗比 NaCl 中的阻抗大得多。最后，在合金调节的培养基中培养的前成骨细胞没有表现出细胞毒性作用，因为没有观察到对细胞增殖和形态的影响。这些数据表明该合金具有生物相容性，表明没有急性毒性，这是将合金集成为生物植入物的先决条件。