Western lifestyle, metaflammation and the cell of origin of colon cancer,Nature Reviews Gastroenterology & Hepatology

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Western lifestyle, metaflammation and the cell of origin of colon cancer
Nature Reviews Gastroenterology & Hepatology ( IF 45.9 ) Pub Date : 2024-07-24 , DOI: 10.1038/s41575-024-00964-7
Mathijs P Verhagen ₁ , Mark Schmitt ₂ , Riccardo Fodde ₁

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Western lifestyles cause a low-grade but chronic and metabolic inflammation (or metaflammation), which might prime committed cell lineages to initiate colon tumorigenesis. At-risk individuals might include cases of early-onset colon cancer, the incidence of which has risen dramatically in the past few decades.

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