With survival rates of critical illness increasing, quality of life measures are becoming an important outcome of ICU treatment. Therefore, to study the impact of critical illness on quality of life, we explored quality of life before and 1 year after ICU admission in different subgroups of ICU survivors. Data from an ongoing prospective multicenter cohort study, the MONITOR-IC, were used. Patients admitted to the ICU in one of eleven participating hospitals between July 2016 and June 2021 were included. Outcome was defined as change in quality of life, measured using the EuroQol five-dimensional (EQ-5D-5L) questionnaire, and calculated by subtracting the EQ-5D-5L score 1 day before hospital admission from the EQ-5D-5L score 1 year post-ICU. Based on the minimal clinically important difference, a change in quality of life was defined as a change in EQ-5D-5L score of ≥ 0.08. Subgroups of patients were based on admission diagnosis. A total of 3913 (50.6%) included patients completed both baseline and follow-up questionnaires. 1 year post-ICU, patients admitted after a cerebrovascular accident, intracerebral hemorrhage, or (neuro)trauma, on average experienced a significant decrease in quality of life. Conversely, 11 other subgroups of ICU survivors reported improvements in quality of life. The largest average increase in quality of life was seen in patients admitted due to respiratory disease (mean 0.17, SD 0.38), whereas the largest average decrease was observed in trauma patients (mean -0.13, SD 0.28). However, in each of the studied 22 subgroups there were survivors who reported a significant increase in QoL and survivors who reported a significant decrease in QoL. This large prospective multicenter cohort study demonstrated the diversity in long-term quality of life between, and even within, subgroups of ICU survivors. These findings emphasize the need for personalized information and post-ICU care. Trial registration: The MONITOR-IC study was registered at ClinicalTrials.gov: NCT03246334 on August 2nd 2017.

中文翻译：

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重症监护后 1 年生活质量的变化：ICU 幸存者的多中心前瞻性队列


随着危重病生存率的提高，生活质量指标正在成为 ICU 治疗的重要结果。因此，为了研究危重疾病对生活质量的影响，我们探讨了 ICU 幸存者不同亚组入住 ICU 前后 1 年的生活质量。使用来自正在进行的前瞻性多中心队列研究 MONITOR-IC 的数据。包括 2016 年 7 月至 2021 年 6 月期间在 11 家参与医院之一入住 ICU 的患者。结果定义为生活质量的变化，使用 EuroQol 五维 （EQ-5D-5L） 问卷测量，并通过从 ICU 后 1 年的 EQ-5D-5L 评分中减去入院前 1 天的 EQ-5D-5L 评分来计算。基于最小的临床重要差异，生活质量的变化定义为 EQ-5D-5L 评分的变化≥ 0.08。患者亚组基于入院诊断。共有 3913 例 （50.6%） 纳入患者，完成了基线和随访问卷。ICU 后 1 年，因脑血管意外、脑出血或（神经）创伤而入院的患者平均生活质量显著下降。相反，其他 11 个 ICU 幸存者亚组报告了生活质量的改善。因呼吸系统疾病入院的患者生活质量的平均增幅最大（平均值 0.17，SD 0.38），而创伤患者的平均下降幅度最大（平均值 -0.13，SD 0.28）。然而，在研究的 22 个亚组中，每个亚组中都有幸存者报告 QoL 显着增加，而幸存者报告 QoL 显着降低。 这项大型前瞻性多中心队列研究表明，ICU 幸存者亚组之间甚至内部的长期生活质量存在差异。这些发现强调了对个性化信息和 ICU 后护理的需求。试验注册：MONITOR-IC 研究于 2017 年 8 月 2 日 ClinicalTrials.gov：NCT03246334注册。