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Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors
Critical Care ( IF 8.8 ) Pub Date : 2024-07-25 , DOI: 10.1186/s13054-024-05036-5
Lucy L Porter 1, 2 , Koen S Simons 2 , Stijn Corsten 3 , Brigitte Westerhof 4 , Thijs C D Rettig 5 , Esther Ewalds 6 , Inge Janssen 7 , Crétien Jacobs 8 , Susanne van Santen 9 , Arjen J C Slooter 10, 11 , Margaretha C E van der Woude 12, 13 , Johannes G van der Hoeven 1 , Marieke Zegers 1 , Mark van den Boogaard 1
Affiliation  

With survival rates of critical illness increasing, quality of life measures are becoming an important outcome of ICU treatment. Therefore, to study the impact of critical illness on quality of life, we explored quality of life before and 1 year after ICU admission in different subgroups of ICU survivors. Data from an ongoing prospective multicenter cohort study, the MONITOR-IC, were used. Patients admitted to the ICU in one of eleven participating hospitals between July 2016 and June 2021 were included. Outcome was defined as change in quality of life, measured using the EuroQol five-dimensional (EQ-5D-5L) questionnaire, and calculated by subtracting the EQ-5D-5L score 1 day before hospital admission from the EQ-5D-5L score 1 year post-ICU. Based on the minimal clinically important difference, a change in quality of life was defined as a change in EQ-5D-5L score of ≥ 0.08. Subgroups of patients were based on admission diagnosis. A total of 3913 (50.6%) included patients completed both baseline and follow-up questionnaires. 1 year post-ICU, patients admitted after a cerebrovascular accident, intracerebral hemorrhage, or (neuro)trauma, on average experienced a significant decrease in quality of life. Conversely, 11 other subgroups of ICU survivors reported improvements in quality of life. The largest average increase in quality of life was seen in patients admitted due to respiratory disease (mean 0.17, SD 0.38), whereas the largest average decrease was observed in trauma patients (mean -0.13, SD 0.28). However, in each of the studied 22 subgroups there were survivors who reported a significant increase in QoL and survivors who reported a significant decrease in QoL. This large prospective multicenter cohort study demonstrated the diversity in long-term quality of life between, and even within, subgroups of ICU survivors. These findings emphasize the need for personalized information and post-ICU care. Trial registration: The MONITOR-IC study was registered at ClinicalTrials.gov: NCT03246334 on August 2nd 2017.

中文翻译:


重症监护后一年生活质量的变化:ICU幸存者的多中心前瞻性队列



随着危重病生存率的提高,生活质量测量正成为 ICU 治疗的重要结果。因此,为了研究危重疾病对生活质量的影响,我们探讨了 ICU 幸存者不同亚组入住 ICU 之前和之后 1 年的生活质量。使用来自正在进行的前瞻性多中心队列研究 MONITOR-IC 的数据。 2016 年 7 月至 2021 年 6 月期间入住 11 家参与医院之一的 ICU 的患者也被纳入其中。结果定义为生活质量的变化,使用EuroQol五维(EQ-5D-5L)问卷进行测量,并通过从入院前1天的EQ-5D-5L评分减去EQ-5D-5L评分来计算ICU 术后 1 年。根据最小的临床重要差异,生活质量的变化定义为 EQ-5D-5L 评分变化≥ 0.08。患者亚组基于入院诊断。共有 3913 名患者 (50.6%) 完成了基线和随访问卷调查。入住 ICU 后 1 年,因脑血管意外、脑出血或(神经)创伤而入院的患者平均生活质量显着下降。相反,ICU 幸存者的其他 11 个亚组报告生活质量有所改善。因呼吸系统疾病入院的患者的生活质量平均提高幅度最大(平均值 0.17,SD 0.38),而平均生活质量下降幅度最大的是创伤患者(平均值 -0.13,SD 0.28)。然而,在所研究的 22 个亚组中,每个亚组中都有幸存者报告生活质量显着提高,也有幸存者报告生活质量显着下降。 这项大型前瞻性多中心队列研究证明了 ICU 幸存者亚组之间甚至内部的长期生活质量存在差异。这些发现强调了个性化信息和 ICU 后护理的必要性。试验注册:MONITOR-IC 研究于 2017 年 8 月 2 日在 ClinicalTrials.gov 注册:NCT03246334。
更新日期:2024-07-25
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