Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling,Cell Stem Cell

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Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling
Cell Stem Cell ( IF 19.8 ) Pub Date : 2024-07-23 , DOI: 10.1016/j.stem.2024.06.015
Rui Chen ₁ , Rui Fan ₁ , Fei Chen ₁ , Niraimathi Govindasamy ₁ , Heike Brinkmann ₁ , Martin Stehling ₂ , Ralf H Adams ₃ , Hyun-Woo Jeong ₄ , Ivan Bedzhov ₁

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Embryonic diapause is a reproductive adaptation that enables some mammalian species to halt the otherwise continuous pace of embryonic development. In this dormant state, the embryo exploits poorly understood regulatory mechanisms to preserve its developmental potential for prolonged periods of time. Here, using mouse embryos and single-cell RNA sequencing, we molecularly defined embryonic diapause at single-cell resolution, revealing transcriptional dynamics while the embryo seemingly resides in a state of suspended animation. Additionally, we found that the dormant pluripotent cells rely on integrin receptors to sense their microenvironment and preserve their viability via Yap/Taz-mediated prosurvival signaling.

中文翻译：

以单细胞分辨率分析胚胎休眠揭示动态转录反应和整合素-Yap/Taz 促生存信号传导的激活

胚胎滞育是一种生殖适应，使某些哺乳动物物种能够停止胚胎发育的持续速度。在这种休眠状态下，胚胎利用人们知之甚少的调节机制来长时间保持其发育潜力。在这里，我们利用小鼠胚胎和单细胞 RNA 测序，以单细胞分辨率对胚胎滞育进行分子定义，揭示了胚胎看似处于假死状态时的转录动态。此外，我们发现休眠的多能细胞依靠整合素受体来感知其微环境并通过 Yap/Taz 介导的促生存信号传导保持其活力。

更新日期：2024-07-23

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