Red Blood Cell-Like Poly(ethylene glycol) Particles: Influence of Particle Stiffness on Biological Behaviors,ACS Macro Letters

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Red Blood Cell-Like Poly(ethylene glycol) Particles: Influence of Particle Stiffness on Biological Behaviors
ACS Macro Letters ( IF 5.1 ) Pub Date : 2024-07-22 , DOI: 10.1021/acsmacrolett.4c00330
Zhiliang Gao ₁ , Hongning Sun ₁ , Shuang Yang ₁ , Mengqi Li ₁ , Na Qi ₁ , Jiwei Cui _{1,

2}

Affiliation

Cell-like particles represent a category of synthetic particles designed to emulate the structures or functions of natural cells. Herein, we present the assembly of cell-like poly(ethylene glycol) (PEG) particles with different stiffnesses and shapes via replication of animal cells and investigate the impact of particle stiffness on their biological behaviors. As a proof of concept, we fabricate red blood cell-like and spherical PEG particles with varying cross-linking densities. A systematic exploration of their properties, encompassing morphology, stiffness, deformability, and biodistribution, reveal the vital influence of particle stiffness on in vivo fate, elucidating its role in governing the traversal of capillaries and the dynamic interactions with phagocytic cells.

中文翻译：

红细胞样聚乙二醇颗粒：颗粒硬度对生物学行为的影响

细胞样颗粒代表一类旨在模拟天然细胞结构或功能的合成颗粒。在此，我们通过动物细胞的复制组装了具有不同硬度和形状的细胞样聚乙二醇（PEG）颗粒，并研究了颗粒硬度对其生物学行为的影响。作为概念验证，我们制造了具有不同交联密度的红细胞样球形 PEG 颗粒。对它们的性质（包括形态、刚度、可变形性和生物分布）的系统探索，揭示了颗粒刚度对体内命运的重要影响，阐明了其在控制毛细血管的穿过以及与吞噬细胞的动态相互作用中的作用。

更新日期：2024-07-22

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