Black Phosphorus Nanosheets-Based Hydrogel for Efficient Bacterial Inhibition and Accelerating Wound Healing,ACS Applied Materials & Interfaces

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Black Phosphorus Nanosheets-Based Hydrogel for Efficient Bacterial Inhibition and Accelerating Wound Healing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2024-07-24 , DOI: 10.1021/acsami.4c06075
Xiaowei Su _{1,

2} , Yunfei Chi ₂ , Tian Liu ₂ , Haoyi Xun _{1,

2} , Yushou Wu _{1,

2} , Xiangyu Liu _{1,

2} , Jinguang Zheng _{1,

2} , Fangchao Hu ₂ , Shaofang Han ₂ , Hongjie Duan ₂ , Jiake Chai _{1,

2}

Affiliation

With the swift evolution of multidrug-resistant bacteria resulting from the intense and inappropriate use of antibiotics, there is a pressing need for innovative solutions. In this study, a thermosensitive hydrogel was developed for efficient bacterial inhibition and promotion of wound healing. The antibacterial chitosan (CS) thermosensitive hydrogel, cross-linked with two-dimensional photothermal nanomaterial black phosphorus (BP) nanosheets through electrostatic interactions, effectively encapsulates and sustains the release of angiogenic drug deferoxamine mesylate (DFO). This facilitates the acceleration of re-epithelialization and neovascularization by enhancing cell migration and proliferation. Following near-infrared (NIR) treatment, this hydrogel demonstrates rapid eradication of the most common multidrug-resistant bacteria encountered in clinical settings, achieved through physical disruption of bacterial membranes and photothermal therapies. Noteworthy is the significant upregulation of IL-19 expression via STAT3 signaling pathways by the BP/CS–DFO hydrogel in a full-thickness wound model. This results in the polarization of the anti-inflammatory M2 macrophage phenotype, altering the microenvironment to a pro-healing state and enhancing extracellular matrix deposition and blood vessel formation. In conclusion, the BP/CS–DFO hydrogel shows immense promise as a potential clinical candidate for wound healing and antimicrobial therapy. Its innovative design and multifunctional capabilities position it as a valuable asset in combating antibiotic resistance and enhancing efficiency in wound healing.

中文翻译：

基于黑磷纳米片的水凝胶可有效抑制细菌并加速伤口愈合

由于抗生素的大量和不当使用导致多重耐药细菌迅速进化，迫切需要创新的解决方案。在这项研究中，开发了一种热敏水凝胶，用于有效抑制细菌和促进伤口愈合。抗菌壳聚糖（CS）热敏水凝胶通过静电相互作用与二维光热纳米材料黑磷（BP）纳米片交联，有效封装并维持血管生成药物甲磺酸去铁胺（DFO）的释放。这通过增强细胞迁移和增殖来促进上皮再形成和新血管形成的加速。经过近红外 (NIR) 治疗后，这种水凝胶通过物理破坏细菌膜和光热疗法，可以快速根除临床环境中最常见的多重耐药细菌。值得注意的是，在全层伤口模型中，BP/CS-DFO 水凝胶通过 STAT3 信号通路显着上调 IL-19 表达。这导致抗炎 M2 巨噬细胞表型的极化，将微环境改变为促愈合状态，并增强细胞外基质沉积和血管形成。总之，BP/CS-DFO 水凝胶作为伤口愈合和抗菌治疗的潜在临床候选者显示出巨大的前景。其创新设计和多功能能力使其成为对抗抗生素耐药性和提高伤口愈合效率的宝贵资产。

更新日期：2024-07-24

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