New Opportunities for Organic Synthesis with Superheated Flow Chemistry,Accounts of Chemical Research

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New Opportunities for Organic Synthesis with Superheated Flow Chemistry
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2024-07-23 , DOI: 10.1021/acs.accounts.4c00340
Pauline Bianchi ₁ , Jean-Christophe M Monbaliu _{1,

2}

Affiliation

Flow chemistry has brought a fresh breeze with great promises for chemical manufacturing, yet critical deterrents persist. To remain economically viable at production scales, flow processes demand quick reactions, which are actually not that common. Superheated flow technology stands out as a promising alternative poised to confront modern chemistry challenges. While continuous micro- and mesofluidic reactors offer uniform heating and rapid cooling across different scales, operating above solvent boiling points (i.e., operating under superheated conditions) significantly enhances reaction rates. Despite the energy costs associated with high temperatures, superheated flow chemistry aligns with sustainability goals by improving productivity (process intensification), offering solvent flexibility, and enhancing safety.

中文翻译：

过热流动化学有机合成的新机遇

流动化学为化学品制造带来了一股清风，带来了巨大的希望，但关键的阻碍因素仍然存在。为了在生产规模上保持经济可行性，流程需要快速反应，但这实际上并不常见。过热流技术作为一种有前途的替代方案脱颖而出，有望应对现代化学挑战。虽然连续微流控和中流控反应器在不同规模上提供均匀加热和快速冷却，但在溶剂沸点以上操作（即在过热条件下操作）可显着提高反应速率。尽管高温会产生能源成本，但过热流动化学通过提高生产率（工艺强化）、提供溶剂灵活性和增强安全性，与可持续发展目标保持一致。

更新日期：2024-07-23

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