Photoswitchable Auxin-Inducible Degron System for Conditional Protein Degradation with Spatiotemporal Resolution,Journal of the American Chemical Society

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Photoswitchable Auxin-Inducible Degron System for Conditional Protein Degradation with Spatiotemporal Resolution
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2024-07-24 , DOI: 10.1021/jacs.4c05135
Saugata Sahu ₁ , Koya Yoshizawa ₂ , Takahiro Yamamoto ₂ , Ryota Uehara _{2,

3} , Nobuyuki Tamaoki _{1,

2}

Affiliation

The auxin-inducible degron (AID) system degrades target proteins rapidly in a controllable manner. Although this is a highly versatile technique for studying protein functionality, protein degradation with spatiotemporal resolution is not currently possible. Herein we describe a photoswitchable AID using a light-active auxin derivative for reversible and site-specific protein degradation with temporal resolution.

中文翻译：

用于具有时空分辨率的条件蛋白质降解的光开关生长素诱导降解子系统

生长素诱导降解决定子（AID）系统以可控方式快速降解靶蛋白。尽管这是一种用于研究蛋白质功能的高度通用的技术，但目前不可能实现时空分辨率的蛋白质降解。在此，我们描述了一种光开关 AID，它使用光活性生长素衍生物来实现具有时间分辨率的可逆和位点特异性蛋白质降解。

更新日期：2024-07-24

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