Achieving high guest loading and multiguest-binding capacity holds crucial significance for advancement in separation, catalysis, and drug delivery with synthetic receptors; however, it remains a challenging bottleneck in characterization of high-stoichiometry guest-binding events. Herein, we describe a large-sized coordination cage (MOC-70-Zn₈Pd₆) possessing 12 peripheral pockets capable of accommodating multiple guests and a high-resolution electrospray ionization mass spectrometry (HR-ESI–MS)-based method to understand the solution host–guest chemistry. A diverse range of bulky guests, varying from drug molecules to rigid fullerenes as well as flexible host molecules of crown ethers and calixarenes, could be loaded into open pockets with high capacities. Notably, these hollow cage pockets provide multisites to capture different guests, showing heteroguest coloading behavior to capture binary, ternary, or even quaternary guests. Moreover, a pair of commercially applied drugs for the combination therapy of chronic lymphocytic leukemia (CLL) has been tested, highlighting its potential in multidrug delivery for combined treatment.

中文翻译：

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多口袋笼能够结合 MS Methodology 发现的高阶笨重和药物客体


实现高客体负载和多客体结合能力对于合成受体的分离、催化和药物输送的进步具有至关重要的意义；然而，它仍然是高化学计量客体结合事件表征中的一个具有挑战性的瓶颈。在此，我们描述了一种大型配位笼（MOC-70-Zn ₈ Pd ₆ ），具有 12 个外围口袋，能够容纳多个客人和高分辨率电喷雾电离质谱仪基于 (HR-ESI-MS) 的方法来了解溶液主客体化学。各种大体积的客体，从药物分子到刚性富勒烯，以及冠醚和杯芳烃的柔性主体分子，都可以装载到具有高容量的开放口袋中。值得注意的是，这些空心笼袋提供了多个位点来捕获不同的客体，表现出异客体共加载行为以捕获二元、三元甚至四元客体。此外，两种用于慢性淋巴细胞白血病（CLL）联合治疗的商业应用药物已经过测试，突显了其在多药递送联合治疗中的潜力。